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Showing 1–3 of 3 results
Advanced filters: Author: Philip Beineke Clear advanced filters

  • In the I-SPY2.2 trial, patients with high-risk stage 2/3 breast cancer received neoadjuvant datopotamab–deruxtecan, followed by sequential chemotherapy with or without targeted therapy, with the option of early surgical resection after each block of therapy. In a subgroup of patients, the sequential treatment strategy was superior to standard of care.

    • Katia Khoury
    • Jane L. Meisel
    • Laura J. Esserman
    Research
    Nature Medicine
    Volume: 30, P: 3728-3736

  • In the I-SPY2.2 trial, patients with high-risk stage 2/3 breast cancer received neoadjuvant datopotamab–deruxtecan plus durvalumab, followed by sequential chemotherapy with or without targeted therapy, with the option of early surgical resection after each block of therapy, showing that de-escalation of therapy is possible for several patient subgroups without compromising outcome and avoiding toxicity of standard chemotherapy.

    • Rebecca A. Shatsky
    • Meghna S. Trivedi
    • Laura J. Esserman
    Research
    Nature Medicine
    Volume: 30, P: 3737-3747

  • Idiopathic multicentric Castleman disease (iMCD) is a life-threatening inflammatory disease requiring immediate intervention, for which the recommended first-line therapy is the Interleukin-6 pathway inhibitor siltuximab. Authors here show that the change in levels of the chemokine CXCL13 shortly following the start of siltuximab treatment is predictive of response.

    • Sheila K. Pierson
    • Laura Katz
    • David C. Fajgenbaum
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13