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Showing 1–2 of 2 results
Advanced filters: Author: Philippa L. Steinberg Clear advanced filters

  • DNA double-stranded breaks threaten genome stability. Here, the authors show that transcript RNA serves as a repair template in human cells and identify Polζ as a key factor in RNA-templated DSB repair. This process can lead to intron deletion, resulting in a mutational signature in cancer genomes.

    • Manisha Jalan
    • Alessandra Brambati
    • Agnel Sfeir
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Age is a risk factor for many diseases, but the impact of aging on molecular phenotypes is not fully understood. Here, the authors quantify the relative contributions of genetics and aging to gene expression patterns across 27 tissues in humans, showing that age and genetics each play distinct roles in shaping expression phenotypes.

    • Ryo Yamamoto
    • Ryan Chung
    • Peter H. Sudmant
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12