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Regulation of glutamate release by presynaptic kainate receptors in the hippocampus

Ramesh Chittajallu
Michel Vignes
Jeremy M. Henley
Research04 Jan 1996
Nature

Volume: 379, P: 78-81
Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes

Dysregulation of H3K4 methylation is associated with neurodevelopmental disorders. Here, the authors perturb H3K4 methylation in the MGE and hypothalamus, resulting in altered gene expression and cell fate as well as changes in behavior that mimic NDD symptoms.

Jianing Li
Anthony F. Tanzillo
Timothy J. Petros
ResearchOpen Access20 Feb 2026
Nature Communications

Volume: 17, P: 1-26
Neurogliaform cells dynamically regulate somatosensory integration via synapse-specific modulation

GABAergic neurogliaform cells are thought to use volume transmission and provide widespread cortical inhibition, indiscriminately. To their surprise, Chittajallu et al. found that that neurogliaform cells exert a spatially restricted inhibitory influence on the mouse canonical thalamocortical circuit, as they selectively suppress feed-forward inhibition while sparing feed-forward excitation.

Ramesh Chittajallu
Kenneth A Pelkey
Chris J McBain
Research09 Dec 2012
Nature Neuroscience

Volume: 16, P: 13-15
Publisher Correction: Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans

Douglas Vormstein-Schneider
Jessica D. Lin
Jordane Dimidschstein
Amendments and Corrections09 Aug 2022
Nature Neuroscience

Volume: 25, P: 1247
Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT_3AR expression

There is a diverse set of cortical interneurons that uniquely participate in the computations of large cell assemblies. Here the authors show that the same type of interneuron within the hippocampus, those projecting to the oriens-lacunosum moleculare, can have distinct developmental origins and different circuit functions.

Ramesh Chittajallu
Michael T Craig
Chris J McBain
Research06 Oct 2013
Nature Neuroscience

Volume: 16, P: 1598-1607
Developmental origin dictates interneuron AMPA and NMDA receptor subunit composition and plasticity

In this study, the authors show that MGE- and CGE-derived GABAergic interneurons exhibit differences in their synaptic receptor composition. In particular, they find that MGE-derived interneuron synapses are dominated by calcium-permeable, GluA2-lacking AMPARs, whereas CGE-derived interneurons use both NMDARs and GluA2-containing AMPARs.

Jose A Matta
Kenneth A Pelkey
Chris J McBain
Research14 Jul 2013
Nature Neuroscience

Volume: 16, P: 1032-1041
Emergence of cortical inhibition by coordinated sensory-driven plasticity at distinct synaptic loci

This study finds that the normal development of GABAergic feedforward inhibition in mouse layer 4 barrel cortex is disrupted by whisker trimming. Such sensory deprivation results in a weakened thalomocortical to feedforward interneuron connections and a lack of the normal reduction of the NMDA component of the thalamocortical input to excitatory cells, both of which are important for feedforward GABAergic inhibition.

Ramesh Chittajallu
John T R Isaac
Research26 Sept 2010
Nature Neuroscience

Volume: 13, P: 1240-1248
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans

This study describes a series of new gene-regulatory sequences that restrict expression of viral transgenes to specific interneuron subtypes, allowing for selective monitoring and manipulation of their activity from mice to humans.

Douglas Vormstein-Schneider
Jessica D. Lin
Jordane Dimidschstein
Research17 Aug 2020
Nature Neuroscience

Volume: 23, P: 1629-1636

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