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Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants

Toxin B (TcdB) is a major exotoxin responsible for diseases associated with C. difficile infection. Here, Tian et al. show that several TcdB subtypes do not recognize the established FZD receptors, and identify a different host protein (TFPI) as a receptor for subtypes TcdB4 and TcdB10.

Songhai Tian
Xiaozhe Xiong
Min Dong
ResearchOpen Access09 Nov 2022
Nature Communications

Volume: 13, P: 1-19
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells

Clostridium difficile toxin A utilizes host sulfated glycosaminoglycans and low-density lipoprotein receptor for host cell entry and intoxication.

Liang Tao
Songhai Tian
Min Dong
Research03 Jun 2019
Nature Microbiology

Volume: 4, P: 1760-1769
Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria

Sirenians are aquatic mammals that originated in Africa ~60 million years ago. Using comparative genomics of a new dugong genome, this study finds genetic adaptations shared by extant sirenians and assessed the diversity of dugongs in Australian waters and the functionally extinct Okinawan dugong.

Ran Tian
Yaolei Zhang
Inge Seim
ResearchOpen Access02 Jul 2024
Nature Communications

Volume: 15, P: 1-19
Self-adjusted synthesis of ordered stable mesoporous minerals by acid–base pairs

Bozhi Tian
Xiaoying Liu
Dongyuan Zhao
Research23 Feb 2003
Nature Materials

Volume: 2, P: 159-163
CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor

A genome-wide CRISPR–Cas9-mediated knockout screen in Drosophila cells identifies Visgun as a proteinaceous receptor for toxin complex toxins, demonstrating the utility of this approach for investigating insecticidal toxins and pathogens.

Ying Xu
Raghuvir Viswanatha
Min Dong
Research28 Sept 2022
Nature

Volume: 610, P: 349-355
Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins

This protocol presents a method for pooled CRISPR perturbation screens to study the intoxication mechanism of bacterial toxins.

Songhai Tian
Yuhang Qin
Min Dong
Protocols01 Nov 2024
Nature Protocols

Volume: 20, P: 1158-1195
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection

Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of a TcdB–CSPG4 complex and CDI mouse models offer insights into CSPG4 role in CDIs and suggest a therapeutic strategy targeting TcdB.

Peng Chen
Ji Zeng
Rongsheng Jin
ResearchOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1-13
A recurrent, homozygous EMC10 frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features

Diane D. Shao
Rachel Straussberg
Christopher A. Walsh
ResearchOpen Access02 Feb 2021
Genetics in Medicine

Volume: 23, P: 1158-1162

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Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants

Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells

Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria

Self-adjusted synthesis of ordered stable mesoporous minerals by acid–base pairs

CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor

Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins

Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection

A recurrent, homozygous EMC10 frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features

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