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Showing 1–2 of 2 results
Advanced filters: Author: Takayuki Atago Clear advanced filters

  • Despite the success of mRNA vaccines, improving the translational efficiency of mRNA therapeutics remains a critical challenge to their widespread clinical application. Here, the authors systematically evaluate chemical modifications to improve the translational activity and stability of uncapped mRNA and show that the 2´-F modification at the first nucleoside of the codon in the open reading frame significantly bolsters the stability of mRNA without compromising its translation.

    • Hiroto Iwai
    • Yasuaki Kimura
    • Hiroshi Abe
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Biomass-derived tricomponent polymers were synthesized consisting of Levoglucosenone, aliphatic dithiol, and dicarboxylic dihydrazide. Sequential treatment of LGO with 1,4-butanedithiol followed by polycondensation with several dicarboxylic dihydrazides resulted in the formation of the corresponding polyhydrazones. All the C-S and C = N bonds were formed stereoselectively, which provided us their optical properties. In addition, these polymers also formed organogels with DMF after further heating. The degree of swelling varied between 170% and 469% depending on the carbon number of the dicarboxylic dihydrazide.

    • Shogo Yashiro
    • Honoka Ishikawa
    • Atsushi Tahara
    Research
    Polymer Journal
    Volume: 57, P: 1165-1175