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Nociceptive sensory neuron-derived NGF orchestrates a fibrotic mesenchymal stromal cell neurogenic niche to drive tendon pathological fibrosis

Nociceptive sensory nerves infiltrate the peripheral trauma area, mediating the biased repair response due to the formation of fibrotic mesenchymal stromal cells (MSCs) neurogenic niche. Nociceptive sensory neuron-derived nerve growth factor activates the TrkA receptors in MSCs and triggers the Hif1α-Twist1 pathway, driving the differentiation of MSCs into myofibroblasts to mediate fibrosis. TPX-0005 exerts therapeutic effects by inhibiting TrkA to reverse fibrosis.

Yanhao Li
Sa Pang
Shen Liu
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 17, P: 1-20
Phytophthora targets plant extracellular vesicles to promote infection

Phytophthora secretes an infection-induced apoplastic lipase, damaging Arabidopsis extracellular vesicles and suppressing plant defence against infection.

Yuanpeng Xu
Xiaoying Kong
Yuanchao Wang
Research20 Apr 2026
Nature Microbiology

Volume: 11, P: 1256-1270
Substrate-based discovery of α-hydroxycarboxylic acid derivatives as potential herbicides targeting dihydroxyacid dehydratase

Dihydroxyacid dehydratase (DHAD) is an essential enzyme for the synthesis of branched-chain amino acids in plants. Here, the authors rationally design a range of DHAD inhibitors as herbicides and present the crystal structure of a lead compound in complex with Arabidopsis DHAD.

Bo He
Yanhao Hu
Yonghao Ye
ResearchOpen Access04 Jun 2025
Nature Communications

Volume: 16, P: 1-12
Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults

Xiao et al. report a weaker adaptive immune response in older adults after inactivated SARS-CoV-2 vaccination compared to young adult controls, identifying altered immune cell function and decreased antigen-specific receptor repertoire diversity as potential underlying mechanisms.

Chanchan Xiao
Zhiyao Ren
Guobing Chen
ResearchOpen Access13 Mar 2023
Nature Aging

Volume: 3, P: 418-435
Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice

Early lipid accumulation is thought to contribute to liver regeneration through unclear functional mechanisms. Here the authors identify an epigenetic regulator, MIER1, that bridges the acute lipid accumulation and cell cycle gene transcription during liver regeneration after surgical resection in male mice.

Yanhao Chen
Lanlan Chen
Qiurong Ding
ResearchOpen Access18 Mar 2023
Nature Communications

Volume: 14, P: 1-18
Doxorubicin promotes the production of inflammatory cytokines in tumor-associated macrophages through activating lactate dehydrogenase A

Bin Liu
Wei Yang
Ting Sun
ResearchOpen Access31 Mar 2026
Cell Death Discovery

Volume: 12, P: 1-11
HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge

Before ovulation, a surge of luteinizing hormone (LH) triggers the resumption of meiosis in oocytes, which is mediated by EGF-like growth factors. Here, the authors show that HDAC3 inhibits mouse oocyte maturation by negatively regulating the expression of EGF-like factor before the LH surge.

Huarong Wang
Han Cai
Chao Wang
ResearchOpen Access16 Dec 2019
Nature Communications

Volume: 10, P: 1-12
Long-term reduced lunar mantle revealed by Chang’e-5 basalt

The lunar mantle may have remained reduced, according to the oxygen fugacity of 2.0 Ga Chang’e-5 basalt that is similar to 3.6 − 3.0 Ga Apollo basalts and pyroclastic glasses.

Huijuan Zhang
Wei Yang
Fuyuan Wu
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-9
Depletion of Ars2 inhibits cell proliferation and leukemogenesis in acute myeloid leukemia by modulating the miR-6734-3p/p27 axis

Xiaoye Hu
Shuangnian Xu
Ning Gao
ResearchOpen Access05 Dec 2018
Leukemia

Volume: 33, P: 1090-1101
A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosome-lysosome fusion through upregulation of BNIP3

Ruoqiu Fu
Qin Deng
Ning Gao
ResearchOpen Access14 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-15
Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration

Xinshu Zhang
Yao Xiao
Shen Liu
ResearchOpen Access07 May 2024
Bone Research

Volume: 12, P: 1-17
High-quality wild barley genome assemblies and annotation with Nanopore long reads and Hi-C sequencing data

Rui Pan
Haifei Hu
Wenying Zhang
ResearchOpen Access10 Aug 2023
Scientific Data

Volume: 10, P: 1-10

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Nociceptive sensory neuron-derived NGF orchestrates a fibrotic mesenchymal stromal cell neurogenic niche to drive tendon pathological fibrosis

Phytophthora targets plant extracellular vesicles to promote infection

Substrate-based discovery of α-hydroxycarboxylic acid derivatives as potential herbicides targeting dihydroxyacid dehydratase

Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults

Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice

Doxorubicin promotes the production of inflammatory cytokines in tumor-associated macrophages through activating lactate dehydrogenase A

HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge

Long-term reduced lunar mantle revealed by Chang’e-5 basalt

Depletion of Ars2 inhibits cell proliferation and leukemogenesis in acute myeloid leukemia by modulating the miR-6734-3p/p27 axis

A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosome-lysosome fusion through upregulation of BNIP3

Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration

High-quality wild barley genome assemblies and annotation with Nanopore long reads and Hi-C sequencing data

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