Nature Search

Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation

Telomerase activity correlates with distinct cell states, but can be challenging to quantify. Here the authors quantify telomerase activity across a range of biological samples using the expression of 13 genes, and show it correlates with cancer cell proliferation and stemness.

Nighat Noureen
Shaofang Wu
Siyuan Zheng
ResearchOpen Access08 Jan 2021
Nature Communications

Volume: 12, P: 1-11
Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering

Myosin VI can facilitate the maturation of autophagosomes in autophagy through interactions with Tom1 and autophagy receptors. Here authors report the structure of the cargobinding domain of Myosin VI in complex with Tom1, which provides insights into Myosin IV’s cargo recognition modes.

Shichen Hu
Yujiao Guo
Lifeng Pan
ResearchOpen Access01 Aug 2019
Nature Communications

Volume: 10, P: 1-12
Molecular bases of the interactions of ATG16L1 with FIP200 and ATG8 family proteins

ATG16L1 is a key autophagic protein. Here, the authors elucidate the molecular basis of ATG16L1 interactions with FIP200 and ATG8 family proteins, showing that the interaction of ATG16L1 with FIP200 is indispensable for the effective autophagic flux.

Xinyu Gong
Yuqian Zhou
Lifeng Pan
ResearchOpen Access10 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Erdafitinib suppresses pathological retinal angiogenesis via dual targeting of FGFR and VEGFR2 signaling

Yingli Mo
Bei Lu
Qinghua Peng
ResearchOpen Access22 Oct 2025
Scientific Reports

Volume: 15, P: 1-10
Coinhibition of the MEK/RTK pathway has high therapeutic efficacy in KRAS-mutant non-small cell lung cancer

Jun Lu
Minjuan Hu
Baohui Han
ResearchOpen Access12 Sept 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-18
Machine learning for cryospheric mass movements: challenges and pathways

Te Pei
Louise Farquharson
Lukas Arenson
ReviewsOpen Access27 Apr 2026
npj Natural Hazards

Volume: 3, P: 1-11
AI-Assisted detection of corneal nerve structural abnormalities in early diabetic keratopathy: development and validation of a deep learning framework

Jiali Pan
Xiaoshuo Shi
Yanning Yang
ResearchOpen Access20 Jan 2026
Scientific Reports

Volume: 16, P: 1-11
Experimental impacts of grazing on grassland biodiversity and function are explained by aridity

Experimental evidence on the long-term impacts of livestock grazing on biodiversity and function is limited. Here, the authors show that grazing impacts on biodiversity and ecosystem functions are aggravated with aridity using experimental sites across an aridity gradient.

Minna Zhang
Manuel Delgado-Baquerizo
Ling Wang
ResearchOpen Access19 Aug 2023
Nature Communications

Volume: 14, P: 1-8
Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation

Cooperation between the ULK complex and autophagy receptors mediates targeting cargoes to autophagosomes. Here, the authors show that interactions of ULK subunit FIP200 with autophagy receptors CCPG1 and Optineurin can be regulated by phosphorylation, suggesting a general binding mode shared by autophagy receptors.

Zixuan Zhou
Jianping Liu
Lifeng Pan
ResearchOpen Access10 Mar 2021
Nature Communications

Volume: 12, P: 1-12
Large-scale identification of adverse drug reaction-related proteins through a random walk model

Xiaowen Chen
Hongbo Shi
Wei Jiang
ResearchOpen Access02 Nov 2016
Scientific Reports

Volume: 6, P: 1-10
AMPK phosphorylates WIP1 to promote DNA repair and radioresistance in cancer cells

Manman Lu
Xiaochuan Dong
Zhenhua Yang
ResearchOpen Access28 Nov 2025
Cell Death & Disease

Volume: 16, P: 1-12
Contrast medium administration with a body surface area protocol in step-and-shoot coronary computed tomography angiography with dual-source scanners

Liang Jin
Yiyi Gao
Ming Li
ResearchOpen Access07 Oct 2020
Scientific Reports

Volume: 10, P: 1-8
Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins

Mutations in optineurin that cause defects in the interaction with TBK1 are associated with neurodegenerative diseases. Here, the authors report the structure of this complex, and outline a general binding mode for these proteins.

Faxiang Li
Xingqiao Xie
Lifeng Pan
ResearchOpen Access13 Sept 2016
Nature Communications

Volume: 7, P: 1-12
Development and validation of a novel endoplasmic reticulum stress-related lncRNA signature in laryngeal squamous cell carcinoma

Xiazhi Pan
Qin Che
Mingbo Liu
ResearchOpen Access11 Apr 2025
Scientific Reports

Volume: 15, P: 1-19
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

Tip60 acetylation of ATM kinase is necessary for DNA double-strand break repair and cancer suppression. Tip60 is recruited to breaks by histoneH3 trimethylated on lysine 9 and the Mre11/Rad50/Nbs1 damage response complex, activating its acetyltransferase activity.

Yingli Sun
Xiaofeng Jiang
Brendan D. Price
Research27 Sept 2009
Nature Cell Biology

Volume: 11, P: 1376-1382
Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition

Bo Jing
Jin Jin
Yingli Wu
ResearchOpen Access22 May 2018
Cell Death & Disease

Volume: 9, P: 1-11
Long-term grazing effects on soil-borne pathogens are driven by temperature

Long-term effects of grazing on soil-borne fungal plant pathogens are strongly controlled by temperature, posing greater potential threats to plant pathogen infections in cooler grasslands.

Yue Wang
Minna Zhang
Ling Wang
ResearchOpen Access26 Nov 2024
Communications Biology

Volume: 7, P: 1-7
A comprehensive analysis of somatic alterations in Chinese ovarian cancer patients

Yingli Zhang
Xiaoliang Shi
Tao Zhu
ResearchOpen Access11 Jan 2021
Scientific Reports

Volume: 11, P: 1-10
Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents

Ni Lin
Xiaobing Zhou
Bo Li
ResearchOpen Access01 Jun 2020
Scientific Reports

Volume: 10, P: 1-15
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB

Xiujian Wang
Xiao Tao
He Huang
ResearchOpen Access22 Oct 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-19
A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation

Cheng-Guo Duan
Xingang Wang
Jian-Kang Zhu
ResearchOpen Access09 Dec 2016
Cell Research

Volume: 27, P: 226-240

Search

Filter By:

Search

Quick links