Takehara et al. screen FDA-approved drugs to identify inhibitors of Clostridium perfringens α-toxin and evaluate their effects in cells and mouse models. Caspofungin reduces α-toxin–induced lethality, tissue damage, and inflammatory responses, highlighting its potential as a therapeutic intervention for gas gangrene.
- Masaya Takehara
- Yuta Homma
- Masahiro Nagahama
