Sir

Stefan Leucht and co-workers have, in two recent reports in the Journal (Leucht and Engel, 2006; Leucht et al, 2006), contributed significantly to the understanding of the clinical relevance of scores on the two rating scales most widely used to evaluate treatment outcomes in schizophrenia patients. They have found that total score changes on the Brief Psychiatric Rating Scale (BPRS) and the Positive and Negative Symptom Scale (PANSS) correlate well with global judgments quantified by the Clinical Global Impression scale (CGI). In the discussion sections of their papers, they underscore the fact that these findings have implications with regard to planning and interpreting clinical trials.

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