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Successful autologous peripheral blood stem cell harvest and transplant in a patient with cold agglutinins

Bone Marrow Transplantation volume 37, pages 329–330 (2006)Cite this article

We wish to comment on the feasibility of peripheral blood stem cell (PBSC) harvest in patients with cold agglutinins, as little has been published on this. High-dose chemotherapy with autologous haemopoietic stem cell rescue is the accepted best treatment of chemotherapy-sensitive relapsed large cell non-Hodgkin's lymphoma (NHL).1 Collection of autologous stem cells by leukapheresis is dependent on adequate venous access and blood flow through extra-corporeal tubing, and requires anticoagulation to prevent clotting within the circuit. Uncommonly, patients with NHL and other B-cell lymphoproliferative disorders may have circulating cold agglutinins, predisposing their blood to clumping when below 37°C, which would interfere with stem cell collection by apheresis.2

We performed successful PBSC harvest and reinfusion in a patient with a cold agglutinin related to relapsed diffuse large B-cell lymphoma (DLBCL). There was no published information on PBSC harvest in patients with cold agglutinins, and, since anecdotal reports from clinicians at other institutions were not encouraging, the procedure was approached cautiously.

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References

  1. Philip T, Chauvin F, Armitage J, Broh D, Hagenbeek A, Biran P et al. J. Parma international protocol:pilot study of DHAP followed by involved field radiotherapy and BEAC with autologous bone marrow transplantation. Blood 1991; 77: 1587–1592.

    CAS  PubMed  Google Scholar 

  2. Robak T . Monoclonal antibodies in the treatment of autoimmune cytopenias. Eur J Haematol 2004; 72: 79–88.

    Article  CAS  Google Scholar 

  3. Hertzberg M, Crombie C, Benson W, Taper J, Gottlieb D, Bradstock K . Outpatient-based ifosfamide, carboplatin and etoposide (ICE) chemotherapy in transplant – eligible patients with non-Hodgkin's lymphoma and Hodgkin's disease. Ann Oncol 2003; 14 (Suppl 1): i11–i16.

    Article  Google Scholar 

  4. Jones HG, Bandarenko N . Management of the therapeutic apheresis patient. In: McLeod B (ed). Apheresis Principles and Practice, 2nd edn. AABB Press: Maryland, 2003.

    Google Scholar 

  5. Sartor M, Garvin F, Antonenas V, Webb M, Bradstock KF . Recovery of viable CD34+ cells from cryopreserved hemopoietic progenitor cell products. Bone Marrow Transplant 2005; 36: 199–204.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Blood and Marrow Transplant Service, Westmead Hospital, Westmead, New South Wales, Australia

    H Crowther, D Collins, M McGurgan, I Kerridge & K Bradstock

  2. Sydney Cellular Therapies Laboratory, Westmead Hospital, Westmead, New South Wales, Australia

    V Antonenas & D Gottlieb

  3. Western Clinical School, University of Sydney, Westmead, New South Wales, Australia

    D Gottlieb

Authors
  1. H Crowther
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  2. D Collins
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  3. V Antonenas
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  4. M McGurgan
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  5. I Kerridge
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  6. D Gottlieb
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  7. K Bradstock
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Corresponding author

Correspondence to K Bradstock.

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Crowther, H., Collins, D., Antonenas, V. et al. Successful autologous peripheral blood stem cell harvest and transplant in a patient with cold agglutinins. Bone Marrow Transplant 37, 329–330 (2006). https://doi.org/10.1038/sj.bmt.1705232

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  • DOI: https://doi.org/10.1038/sj.bmt.1705232

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