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Allogeneic bone marrow transplantation in a child with severe aplastic anemia and hemophilia A

Bone Marrow Transplantation volume 37, pages 627–628 (2006)Cite this article

Hemophilia A is an X-linked bleeding disorder due to mutation of the factor VIII (FVIII) gene. This results in either defective or deficient production of FVIII, a nonenzymatic co-factor in the coagulation cascade. Hemophilia A is the most common form, affecting one in 5000 males.1

The combination of hemophilia and aplastic anemia in the same patient is very uncommon. Hypoplastic anemia has been described in patients with hemophilia, and is usually associated with human parvovirus-B19 infection.2, 3

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Authors and Affiliations

  1. Hematology and BMT Unit, Real-Hospital Português, Av. Agamenon Magalhães, s/n Recife, Pernambuco, Brazil

    M Ostronoff, F Ostronoff, G Campos, S Arruda, C Vaz, R Florencio, R Calixto, A P Souto Maior, A Sucupira, M Domingues & C Tagliari

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  2. F Ostronoff
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  3. G Campos
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Ostronoff, M., Ostronoff, F., Campos, G. et al. Allogeneic bone marrow transplantation in a child with severe aplastic anemia and hemophilia A. Bone Marrow Transplant 37, 627–628 (2006). https://doi.org/10.1038/sj.bmt.1705292

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