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Hemophagocytic syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma; successful treatment with high-dose intravenous immunoglobulin

Bone Marrow Transplantation volume 37, pages 797–798 (2006)Cite this article

The hemophagocytic syndrome (HPS) is a clinicopathological entity characterized by macrophage or histiocyte activation and marked hemophagocytosis in bone marrow (BM) and other parts of the reticuloendothelial system, resulting in cytopenias.1 Primary or familial HPS is genetically mediated and usually occurs in childhood.2 Secondary or reactive HPS (R-HPS) is associated with infections, malignancies and autoimmune disorders.3

We describe a case of R-HPS with life-threatening gastrointestinal (GI) tract bleeding after autologous peripheral stem cell transplantation (APSCT) for multiple myeloma (MM), which resolved after high-dose intravenous immunoglobulin (IVIG) therapy.

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Authors and Affiliations

  1. Real TMO-Bone Marrow Transplantation Program of the Real Hospital Portugues, Recife, Brazil

    M Ostronoff, F Ostronoff, M Coutinho, R Calixto, A P Souto Maior, A Sucupira, R Florencio & C Tagliari

Authors
  1. M Ostronoff
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  2. F Ostronoff
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  3. M Coutinho
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  4. R Calixto
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  5. A P Souto Maior
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  7. R Florencio
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  8. C Tagliari
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Ostronoff, M., Ostronoff, F., Coutinho, M. et al. Hemophagocytic syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma; successful treatment with high-dose intravenous immunoglobulin. Bone Marrow Transplant 37, 797–798 (2006). https://doi.org/10.1038/sj.bmt.1705329

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