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Early relapses do not impact survival after autologous stem cell transplantation in African Americans with multiple myeloma

Bone Marrow Transplantation volume 39, pages 727–728 (2007)Cite this article

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African Americans are twice as likely to suffer from multiple myeloma and the mortality is twice as high as that of Caucasian Americans.1 Although multiple myeloma seems to be more aggressive in African Americans, little is known regarding outcomes of high-dose chemotherapy and autologous stem cell transplantation in this population. A recent retrospective analysis comparing outcomes after high-dose chemotherapy and autologous stem cell transplantation in 38 African American patients with multiple myeloma to 32 non-African American patients found no difference in overall survival between the two groups and improved progression-free survival in African Americans.2

We have conducted a similar retrospective review of 86 consecutive patients (32 African Americans and 54 non-African Americans) who underwent high-dose chemotherapy and autologous stem cell transplantation for multiple myeloma between July 1991 and November 2004 at our institution and also found no difference in overall survival but a shorter progression-free survival.

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References

  1. SEER database. http://seer.cancer.gov/, last accessed 12/16/06.

  2. Saraf S, Chen YH, Dobogai LC, Mahmud N, Hoffman R, Rondelli D et al. Prolonged responses after autologous stem cell transplantation in African-American patients with multiple myeloma. Bone Marrow Transplant 2006; 37: 1099–1102.

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Authors and Affiliations

  1. Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, MI, USA

    Y Khaled, K Kato, J L M Ferrara & S Mineishi

  2. Bone Marrow Transplant Program, Henry Ford Hospital, Ann Arbor, MI, USA

    N Janakiraman

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  1. Y Khaled
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  2. K Kato
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  3. N Janakiraman
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  4. J L M Ferrara
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  5. S Mineishi
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Correspondence to Y Khaled.

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Khaled, Y., Kato, K., Janakiraman, N. et al. Early relapses do not impact survival after autologous stem cell transplantation in African Americans with multiple myeloma. Bone Marrow Transplant 39, 727–728 (2007). https://doi.org/10.1038/sj.bmt.1705660

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