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Mechanism of action on B cell lymphoma by chimeric anti-CD20 monoclonal antibody

Leukemia volume 15, page 1667 (2001)Cite this article

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Anti-CD20 chimeric monoclonal antibody (CD20-ab) has been demonstrated to be effective for the treatment of low-grade B cell lymphoma. Although complement-mediated cytotoxicity (CDC) and antibody-dependent cytotoxicity (ADCC) are thought to have an inhibitory effect on tumor cells in vivo, the exact mechanism of cell death remains to be clarified.

The action mechanism of an antibody in vivo may not be regarded as an important issue as long as the antibody is a single therapeutic agent, but it becomes important when it is used in conjunction with other therapies, such as chemotherapy. If direct suppression is caused partly by apoptosis as shown in our previous experiment, enhancement of such a pathway needs to be considered. If ADCC is the major pathway, the chemotherapeutic adverse effect on effector cells should be thoroughly examined. The results of such an investigation can be expected to provide a strategic rationale for combination chemotherapy with CD20-ab. In this context, several protocol studies being examined4 that varied the time of antibody inoculation, may explore important insights into the major in vivo tumoricidal mechanism.

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Authors and Affiliations

  1. Department of Hematology and Chemotherapy, Aichi Cancer Center, Nagoya, Japan

    T Oyama, Y Kagami & Y Morishima

  2. Division of Molecular Medicine, Aichi Cancer Center, Nagoya, Japan

    M Seto

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  1. T Oyama
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  2. Y Kagami
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  3. M Seto
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  4. Y Morishima
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Oyama, T., Kagami, Y., Seto, M. et al. Mechanism of action on B cell lymphoma by chimeric anti-CD20 monoclonal antibody. Leukemia 15, 1667 (2001). https://doi.org/10.1038/sj.leu.2402242

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