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Response to Garcia-Pardo

Leukemia volume 16, page 1397 (2002)Cite this article

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We are aware that Casanova et al1 were not responsible for the original mapping of RARRES3, however, inconsistencies in gene positions need to be highlighted following publication of the human genome sequence. The GenBank accession NM—004585 references the DiSepio paper and localises RARRES3 to within cosmid 187d6. The NCBI Map Viewer, which provides a graphical display of the human genomic sequence data, place RARRES3 within the NT—009296.5. contig at 11q12. BLAST analysis produces significant alignment with four different overlapping 11q12 BAC clones, RP-11 838I13 (AC090088), CMB9–14B22 (AP000484), CTC-343D6 (AC090271) RP-11 660B16 (AC073228), including ones mapped by FISH to 11q12. This confirms the localisation of RARRES3 to 11q12 by at least two methodologies. In addition, it is worth consideration that the original mapping data for cosmid 187D6 was based only on a short sequence of homology and is at best weak. It is of importance that the mistaken placing of RARRES3 to 11q23 is not perpetuated. In our opinion it would be appropriate that the authors acknowledge this for the benefit of future research in CLL.

Whilst we appreciate that the authors have shown down-regulation of RARRES3, which correlates with progression of CLL, this gene cannot be considered responsible for the 11q22–3 deletions associated with aggressive CLL. We do not dispute their findings for the RARRES3 gene and consider this of interest.

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References

  1. Casanova B, de la Fuente MT, Garcia-Gila M, Sanz S, Silva JA, Garcia-Marco JA, Garcia-Pardo A . The class II tumor-suppressor gene RARRES3 is expressed in B cell lymphocytic leukemias and down-regulated with disease progression Leukemia 2001 15: 1521–1526

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  1. Department of Experimental Hematology, Bart's and the London School of Medicine, London, UK

    RL Auer

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Auer, R. Response to Garcia-Pardo. Leukemia 16, 1397 (2002). https://doi.org/10.1038/sj.leu.2402507

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