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Sequence conservation of RAG-1 and RAG-2 genes in hematologic malignancies

Leukemia volume 16, page 1571 (2002)Cite this article

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The diversity of the immune repertoire is due to a physiological process of somatic gene rearrangement directed by the V(D)J recombinase. The products of the RAG-1 and RAG-2 genes drive the molecular process of assembly of immunoglobulin and T cell antigen receptor genes. The expression of RAG genes is not restricted to immature lymphocyte populations in the thymus and bone marrow but they are also functional in germinal center B cells.1,2,3,4

It has been postulated that certain chromosomal translocations could be attributed to an illegitimate recombinase activity of this enzymatic complex. Earlier studies have demonstrated that RAG-1 is expressed in a stage-specific manner among acute lymphoblastic leukemia(ALL)/lymphoblastic lymphoma (LBL) cells.5

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Authors and Affiliations

  1. Department of Hematology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain

    MC Mulero, C Estivill, J Sierra & JF Nomdedéu

  2. Department of Genetics, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain

    M Baiget

  3. Department of Hematology, Hospital Morales Meseguer, Murcia, Spain

    J Corral

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  1. MC Mulero
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  2. C Estivill
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  3. J Corral
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  4. J Sierra
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  5. M Baiget
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  6. JF Nomdedéu
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Mulero, M., Estivill, C., Corral, J. et al. Sequence conservation of RAG-1 and RAG-2 genes in hematologic malignancies. Leukemia 16, 1571 (2002). https://doi.org/10.1038/sj.leu.2402518

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