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T-cell ZAP-70 overexpression in chronic lymphocytic leukemia (CLL) correlates with CLL cell ZAP-70 levels, clinical stage and disease progression

Leukemia volume 19, pages 1289–1291 (2005)Cite this article

TO THE EDITOR

In recent years it has become evident that there are two major subgroups of chronic lymphocytic leukemia (CLL) based on IgVH mutational status of the CLL leukemic cells.1 CLL patients with unmutated IgVH generally have more aggressive disease characterized by clinical progression, a more advanced stage and a shorter overall survival.1 Recently, using DNA microarray analysis it has been shown that ZAP-70 is highly expressed in CLL patients with unmutated status, while the mutated group usually has low ZAP-70 expression.2 Subsequent studies with larger numbers of CLL patients demonstrated that ZAP-70 expression in CLL cells can predict the mutational status, and that ZAP-70 levels also correlate with disease progression, and overall survival.3, 4

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Author notes

  1. Y Herishanu and S Kay: These authors contributed equally to this work

Authors and Affiliations

  1. Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

    Y Herishanu, S Kay, O Rogowski, M Pick, E Naparstek & V R Deutsch

  2. Department of Hematology Hadassah University Hospital, Jerusalem, Israel

    A Polliack

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  1. Y Herishanu
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  2. S Kay
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  3. O Rogowski
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  4. M Pick
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  5. E Naparstek
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  6. V R Deutsch
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  7. A Polliack
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Correspondence to Y Herishanu.

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Herishanu, Y., Kay, S., Rogowski, O. et al. T-cell ZAP-70 overexpression in chronic lymphocytic leukemia (CLL) correlates with CLL cell ZAP-70 levels, clinical stage and disease progression. Leukemia 19, 1289–1291 (2005). https://doi.org/10.1038/sj.leu.2403762

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