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RBM15 and MKL1 mutational screening in megakaryoblastic leukemia cell lines and clinical samples

Leukemia volume 19, pages 1492–1494 (2005)Cite this article

TO THE EDITOR

At least three subtypes of human acute megakaryoblastic leukemia (AMKL) exist: (1) pediatric de novo AMKL, which is associated with a characteristic t(1;22)(p13;q13) in approximately two-thirds of AMKL in infants, (2) pediatric AMKL in the setting of Down Syndrome, and (3) adult AMKL.1 We and others recently reported the involvement of two novel genes, RBM15 (alternatively known as OTT) and MKL1 (alternative name, MAL), in the t(1;22) associated with de novo infant and early childhood AMKL.2, 3 In addition, mutations of the GATA-1 transcription factor gene are associated with the transient leukemias (TLs) and AMKLs associated with Down Syndrome, and are hypothesized to contribute to their development.4, 5, 6

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References

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Acknowledgements

This research was supported in part by grant CA-87064 (to SWM) and Cancer Center Support (CORE) grant CA-27165 – both from the National Cancer Institute, by the American Lebanese Syrian Associated Charities (ALSAC), St Jude Children's Research Hospital, and by The Hospital for Sick Children Foundation. We thank Dr Shinpei Nakazawa (Department of Pediatrics, University of Yamanashi, Nakakoma-gun, Japan), and Drs Toshiji Shitara and Noriyuki Suetake (Department of Pediatrics, Gunma University, Gunma, Japan), for assistance in providing us with the KOPMK42 cell line for these studies. The SET-2 cell line was kindly provided by Dr Kimiharu Uozumi (Second Department of Internal Medicine, Kagoshima University, Kagoshima, Japan).

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Authors and Affiliations

  1. Department of Pediatrics, Tokyo Dental College, Ichikawa General Hospital, Tokyo, Japan

    H Kawaguchi

  2. Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA

    H Kawaguchi, Z Ma & S W Morris

  3. Department of Paediatrics – Division of Haematology/Oncology, Program in Developmental Biology, The Hospital for Sick Children, Toronto, M5G 1X8, Ontario, Canada

    J K Hitzler

  4. Department of Hematology, Huaxi Hospital, Sichuan University, Chengdu, 610041, P.R. China

    Z Ma

  5. Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, 38105, TN, USA

    S W Morris

  6. Department of Pediatrics, University of Tennessee, College of Medicine, Memphis, 38163, TN, USA

    S W Morris

Authors
  1. H Kawaguchi
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  2. J K Hitzler
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  3. Z Ma
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  4. S W Morris
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Corresponding author

Correspondence to S W Morris.

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Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu).

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Kawaguchi, H., Hitzler, J., Ma, Z. et al. RBM15 and MKL1 mutational screening in megakaryoblastic leukemia cell lines and clinical samples. Leukemia 19, 1492–1494 (2005). https://doi.org/10.1038/sj.leu.2403812

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