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Does vitamin C have a pro-oxidant effect?

Nature volume 395, pages 231–232 (1998)Cite this article

Abstract

Podmore et al.1 reported a decrease in 8-oxo-7,8-dihydroguanine and an increase in 8-oxo-7,8-dihydroadenine in lympho-cyte DNA after intake of 500 milligrams of vitamin C daily for 6 weeks. In our view, four issues compromise the validity of their findings.

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References

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Authors and Affiliations

  1. Department of Clinical Pharmacology Q 7642, Rigshospitalet, University of Copenhagen, DK-2200, Copenhagen N, Denmark

    Henrik E. Poulsen & Allan Weimann

  2. Research Institute of Public Health, University of Kuopio, FIN-70211, Kuopio, Finland

    Jukka T. Salonen & Kristiina Nyyssönen

  3. Institute of Public Health, University of Copenhagen, Panum 18-5, DK-2100, Copenhagen, Denmark

    Steffen Loft

  4. DRFMC/SCIB, Laboratoire Lésions des Acides Nucléiques, CEA/Grenoble, Grenoble, F-38054 Cedex 9, France

    Jean Cadet, Thierry Douki & Jean-Luc Ravanat

Authors
  1. Henrik E. Poulsen
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  2. Allan Weimann
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  3. Jukka T. Salonen
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  4. Kristiina Nyyssönen
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  5. Steffen Loft
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  6. Jean Cadet
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  7. Thierry Douki
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  8. Jean-Luc Ravanat
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Poulsen, H., Weimann, A., Salonen, J. et al. Does vitamin C have a pro-oxidant effect?. Nature 395, 231–232 (1998). https://doi.org/10.1038/26139

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