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DNA metabolism

… and from repair to remodelling

Nature Reviews Molecular Cell Biology volume 1, page 7 (2000)Cite this article

Molecules identified in one process are increasingly being implicated in other — often unexpected — pathways. Take the TIP60 protein, for example. Originally isolated as a protein that interacts with HIV-1 Tat, it was subsequently shown to be a histone acetyltransferase. And now, according to a paper by Yoshihiro Nakatani and collaborators in Cell, TIP60 may also be involved in DNA repair and apoptosis.

The first step was purification of the TIP60 complex from HeLa cells. Initial studies of TIP60's histone acetyltransferase activity had used TIP60 monomers, and there was a problem with that — activity was detected only when free histones were used, and not with the more physiologically relevant nucleosomes. But Nakatani and colleagues showed that the TIP60 complex, which contains at least 14 subunits, can acetylate both substrates.

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References

ORIGINAL RESEARCH PAPER

  1. Ikura, T. et al. Involvement of the TIP60 histone acetyltransferase complex in DNA repair and apoptosis. Cell 102, 463–473 (2000)

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REVIEW

  1. Sterner, D. E. & Berger, S. L. Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev. 64, 435–459 ( 2000)

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Authors
  1. Alison Mitchell
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Mitchell, A. … and from repair to remodelling . Nat Rev Mol Cell Biol 1, 7 (2000). https://doi.org/10.1038/35036020

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