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Technologies and techniques
In this article series, Nature Reviews Molecular Cell Biology focuses on recent technological and technical advances and on their impact on diverse areas of molecular and cell biology. The articles highlight important biological issues, describe the technologies and techniques that were developed to tackle them and discuss the wealth of knowledge that using them has produced.
Image: Vicky Summersby -
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4D nucleome
The 4D Nucleome (4DN) program, funded by the National Institutes of Health Common Fund, was established in 2015 to map the three-dimensional organization of the nucleus in space and time (the 4th dimension).
Image: Frank Alber and Ye Wang -
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The secretory pathway
Secreted proteins exit the ER at defined sites and travel in vesicles to the Golgi, where they are modified and sorted for transport to the plasma membrane.
Image: Vicky Summersby -
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DNA damage repair
In this article series, Nature Reviews Molecular Cell Biology explores the pathways that preserve genomic integrity by detecting and repairing damage in different types of cellular DNA, highlighting new control mechanisms in the DNA damage response and the implications of disrupted repair pathways for disease.
Image: Vicky Summersby -
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Structure–function
The functions of biomolecules, including lipids, nucleic acids and especially proteins are determined to a great extent by their structure. This structure–function relationship is a foundation of many physiological processes. In this article series, Nature Reviews Molecular Cell Biology collates Reviews that present important structural findings and illuminate their mechanistic and functional significance.
Image: Science Lab / Alamy Stock Photo -
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A year of stem cell and developmental biology
In recent years, the field of stem cell and developmental biology has seen remarkable breakthroughs that have deepened our understanding of how organisms grow, age and regenerate, with major implications for medicine and biotechnology.
Image: Dr. Christopher Thomas, Marseille Developmental Biology Institute (IBDM), CNRS & Aix-Marseille Université -
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RNA splicing
Technological and computational advances in recent years, from cryo-electron microscopy to sequencing technologies and machine learning
Image: Patrick Morgan -
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RNA processing and modifications
This series of articles by Nature Reviews Molecular Cell Biology highlights different aspects of the biogenesis of various RNA species.
Image: Vicky Summersby -
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Cell senescence
Cell senescence — a state of irreversible cell-growth arrest — has important physiological functions and is a key driver of ageing.
Image: Vicky Summersby -
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Nobel Prize in Chemistry 2024
The 2024 Nobel Prize in Chemistry has been awarded to David Baker “for computational protein design” and to Demis Hassabis and John M. Jumper “for protein structure prediction”.
Image: Springer Nature/The Nobel Foundation/Imagesource -
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Nobel Prize in Physiology or Medicine 2024
The 2024 Nobel Prize in Physiology or Medicine has been awarded jointly to Victor Ambros and Gary Ruvkun "for the discovery of microRNA and its role in post-transcriptional gene regulation".
Translation and protein quality control
