TABLE 1 Relations of Lung Adenocarcinoma Differentiation with Telomerase Activity and Chromosome Alterations

Case	Age	Sex	Adenocarcinomas
			Stage	Size^a (cm)	Differentiation	Electron Microscopic Classification	Telomerase Activity	Chromosome Alterations	T-C Index^b
1	67	F	1	2.1	Well	Clara	2	1	2
2	58	F	3b	5.0	Well	Clara	1	0	0
3	54	F	1	3.7	Well	Clara	0	0	0
4	54	M	1	1.5	Well	Clara	2	1	2
5	67	M	2	6.0	Well	Mixed	1	3	3
6	73	F	3a	3.2	Well	Clara	1	1	1
7	80	M	1	2.5	Well	Clara	0	2	0
8	59	F	1	2.2	Well	Fuzzy Clara	1	2	2
9	64	F	1	2.0	Well	Clara	0	0	0
10	76	M	1	4.4	Well	Bronchial surface^c	2	0	0
M ± SD				3.3 ± 1.4			1.0 ± 0.8^d	1.0 ± 1.1^e	1.0 ± 1.2^f
11	57	M	3a	6.8	Moderately	Mixed	1	1	1
12	58	M	3a	4.0	Moderately	Fuzzy Clara	3	1	3
13	69	M	1	2.3	Moderately	Mixed	1	2	2
14	53	F	3a	2.8	Moderately	Fuzzy Clara	3	3	9
15	68	F	1	2.6	Moderately	Mixed	2	2	4
16	72	M	3a	2.0	Moderately	Bronchial surface	2	3	6
17	50	M	3a	2.5	Moderately	Bronchial surface	2	3	6
18	59	M	1	3.7	Moderately	Bronchial surface	2	3	6
M ± SD				3.3 ± 1.6			2.0 ± 0.8	2.3 ± 0.9	4.6 ± 2.6
19	64	M	3b	7.0	Poorly	Bronchial surface	3	2	6
20	53	M	3a	4.0	Poorly	Bronchial surface	2	2	4
21	48	M	1	3.0	Poorly	Mixed	2	3	6
22	66	M	1	3.5	Poorly	Mixed	2	3	6
23	51	M	3b	3.5	Poorly	Fuzzy Clara	3	3	9
24	59	M	4	6.0	Poorly	Mixed	2	1	2
25	56	M	2	3.5	Poorly	Mixed	3	1	3
M ± SD				4.4 ± 1.5			2.4 ± 0.5	2.1 ± 0.9	5.1 ± 2.3

^aThe largest diameter.
^bTelomerase activity-chromosome alteration index, multiplication of telomerase activity and chromosome alteration scores.
^cBronchial surface epithelial type.
^dSignificantly different from moderately (p = .0330) or poorly differentiated types (p = .0047).
^eSignificantly different from moderately (p = .0368) or poorly differentiated types (p = .0248).
^fSignificantly different from moderately (p = .0039) or poorly differentiated types (p = .0018).

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