FIGURE 1 | Modern Pathology

FIGURE 1

From: Strong Correlation between Results of Fluorescent In Situ Hybridization and Immunohistochemistry for the Assessment of the ERBB2 (HER-2/neu) Gene Status in Breast Carcinoma

FIGURE 1

FISH of ERBB2 probe on paraffin-embedded tissue sections of three cases of breast carcinoma. A, tumor without amplification. A mean number of two signals per nucleus is observed. B, tumor with a high level amplification. Presence of numerous signals, arranged in clusters. C, tumor with the lowest amplification (dual color FISH): presence of five to six signals of the ERBB2 probe (red) and two centromeres of chromosome 17 (green).

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