Table 2 Summary of Immunohistochemical Abnormalities in PanIN Lesions
Protein | Normal Duct Epithelium | PanIN 1A | PanIn 1B | PanIn 2 | PanIN 3 | P-value* |
|---|---|---|---|---|---|---|
p16 | Present | 5/16 (31%) | 8/18 (44%) | 7/14 (50%) | 6/7 (85%) | NS |
MUC5 | Absent | 12/16 (75%) | 13/18 (72%) | 13/14 (93%) | 7/7 (100%) | NS |
PSCA | Absent | 7/16 (43%) | 5/18 (28%) | 6/14 (43%) | 4/7 (57%) | NS |
Fascin | Absent | 4/16 (25%) | 5/18 (28%) | 8/14 (57%) | 4/7 (57%) | 0.0471 |
14-3-3σ | Absent | 2/16 (13%) | 2/18 (11%) | 3/14 (21%) | 6/7 (85%) | 0.0220 |
MUC1 | Present | 1/16 (6%) | 1/18 (5%) | 6/14 (43%) | 6/7 (85%) | <0.0001 |
Mesothelin | Absent | 1/16 (6%) | 0 | 2/14 (14%) | 1/7 (14%) | NS |
Cyclin D1 | Absent | 0 | 0 | 4/14 (29%) | 4/7 (57%) | 0.0003 |
Ki-67 | Absent | 0 | 0 | 1/14 (7%) | 5/7 (71%) | 0.0037 |
Topo II | Absent | 0 | 0 | 1/14 (7%) | 5/7 (71%) | 0.0037 |
p53 | Absent | 0 | 0 | 0 | 4/7 (57%) | 0.0351 |
Dpc4/Smad4 | Present | 0 | 0 | 0 | 2/7 (28%) | NS |
MUC2 | Absent | 0 | 0 | 0 | 0 | NS |
Beta-catenin (nuclear) | Absent | 0 | 0 | 0 | 0 | NS |
