Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?

Dear Editor,

DIABLO/Smac is a mammalian protein that promotes apoptosis by binding to inhibitor of apoptosis (IAP) proteins.^1,2 Chai et al.³ and Srinivasula et al.⁴ have shown that the N-terminal 4 amino acids or processed DIABLO/Smac are necessary, and the first 7 amino acids are sufficient, for this interaction, just as the N-terminal residues of the insect pro-apoptotic proteins Grim, Reaper and Hid are required for the interaction with insect IAPs.^5,6

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