Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown

Mihalik, R; Imre, G; Petak, I; Szende, B; Kopper, L

doi:10.1038/sj.cdd.4401493

Letter to the Editor
Published: 06 August 2004

Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown

R Mihalik¹,
G Imre²,
I Petak²,
B Szende^1,2 &
…
L Kopper^1,2

Cell Death & Differentiation volume 11, pages 1357–1360 (2004)Cite this article

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Dear Editor,

Recent progress provided compelling evidence for the major role of lysosomal cathepsin proteases in cell death pathways especially when caspase activity is suppressed.^{1, 2} Cathepsin B, a ubiquitous endopeptidase and ectodipeptidase, was shown to be a component of TNF-α cell death signaling,³ as well as an executor protease in caspase-compromised cells induced to undergo apoptosis⁴ or necrosis.⁵

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Acknowledgements

This work was supported by grants from the National Science Foundation, Hungary, OTKA-T029611 and Ministry of Welfare, Hungary, ETT-183/2000. (I Petak was supported by Zoltan Magyary Scholarship, OTKA-T046665, ETT 145/2003, NKFP-1A/20/2002 and I-48/2003 grants, L Kopper was supported by OTKA-T034892.)

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Authors and Affiliations

Molecular Pathology Research. Joint Research Organization of Hungarian Academy of Science and Semmelweis University, Budapest
R Mihalik, B Szende & L Kopper
Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
G Imre, I Petak, B Szende & L Kopper

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R Mihalik
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G Imre
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I Petak
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B Szende
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L Kopper
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Correspondence to R Mihalik.

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Mihalik, R., Imre, G., Petak, I. et al. Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown. Cell Death Differ 11, 1357–1360 (2004). https://doi.org/10.1038/sj.cdd.4401493

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Published: 06 August 2004
Issue date: 01 December 2004
DOI: https://doi.org/10.1038/sj.cdd.4401493

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Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown

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Dysfunction of Membrane Trafficking Leads to Ischemia-Reperfusion Injury After Transient Cerebral Ischemia

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