Nuclear localisation of FADD – rebuttal

Dear Editor,

We recently published in your journal a paper describing the subcellular localisation and post-translational modifications of caspase-8 and its adaptor FADD (also called Mort1) in unstimulated cells, and in lymphocytes that had been activated with mitogens or treated with FasL.¹ In their letter, Frisch et al. question some of the conclusions from our work, specifically our conclusion that FADD is located exclusively in the cytoplasm, since they found significant amounts of FADD in the nucleus, at least in adherent cells.

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