Yes-Associated Protein (YAP) is a critical mediator of c-Jun-dependent apoptosis

Dear Editor,

c-Jun plays an important role in the cellular response to DNA damage. Following UV irradiation, c-Jun is rapidly induced and blocks p53-mediated upregulation of p21. c-Jun is required for re-entering the cell cycle following p53-mediated G1 arrest,¹ as c-Jun-null MEFs undergo a prolonged growth arrest following UV irradiation. Consequently, these cells show increased resistance to p53-dependent apoptosis.¹ Moreover, c-Jun is also important for the DNA repair response following cisplatin treatment. Following DNA damage, c-Jun/ATF complexes are rapidly recruited to the promoters of known DNA repair genes such as MSH2 and 6, Rad50 and ATM.² Although c-Jun promotes efficient DNA repair upon DNA damage, c-Jun also contributes to DNA damage-mediated apoptosis. This is evident because c-Jun-deficient MEFs demonstrate enhanced resistance to cisplatin-induced apoptosis,^{3, 4} indicating a role of c-Jun in chemosensitivity.

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