Alexander D. Gitlin and Michel C. Nussenzweig reflect on the discovery of two lineages of adaptive immune cells, and how it influenced vaccination, cancer therapy and the development of a class of antibody-based drugs.
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References
Cooper, M. D., Peterson, R. D. A. & Good, R. A. Nature 205, 143–146 (1965).
Burnet, F. M. The Clonal Selection Theory of Acquired Immunity (Vanderbilt Univ. Press, 1959).
Talmage, D. W. Science 129, 1643–1648 (1959).
Miller, J. F. A. P. Immunol. Rev. 185, 7–14 (2002).
Cooper, M. D. A. Ann. Rev. Immunol. 28, 1–19 (2009).
Glick, B., Chang, T. S. & Jaap, R. G. Poultry Sci. 35, 224–225 (1956).
Cooper, M. D., Raymond, D. A., Peterson, R. D., South, M. A. & Good, R. A. J. Exp. Med. 123, 75–102 (1966).
Owen, J. J. T., Cooper, M. D. & Raff, M. C. Nature 249, 361–363 (1974).
Köhler, G. & Milstein, C. Nature 256, 495–497 (1975).
Hozumi, N. & Tonegawa, S. Proc. Natl Acad. Sci. USA 73, 3628–3632 (1976).
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Gitlin, A., Nussenzweig, M. Immunology: Fifty years of B lymphocytes. Nature 517, 139–141 (2015). https://doi.org/10.1038/517139a
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DOI: https://doi.org/10.1038/517139a
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