Heritable human genetic modifications pose serious risks, and the therapeutic benefits are tenuous, warn Edward Lanphier, Fyodor Urnov and colleagues.
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References
Regalado, A. MIT Tech. Rev. http://go.nature.com/2n2nfl (2015).
Urnov, F. D., Rebar, E. J., Holmes, M. C., Zhang. H. S. & Gregory, P. D. Nature Rev. Genet. 11, 636–646 (2010).
Carroll, D. Annu. Rev. Biochem. 83, 409–439 (2014).
Tebas, P. et al. N. Engl. J. Med. 370, 901–910 (2014).
Yoshimi, K., Kaneko, T., Voigt, B. & Mashimo, T. Nature Commun. 5, 4240 (2014).
Heo, T. Y. et al. Stem Cells Dev. 24, 393–402 (2015).
Han, H. et al. Front. Agr. Sci. Eng. 1, 2–5 (2014).
Kang, Q. et al. in Proc. 10th World Congr. Genet. Appl. Livestock Prod. http://go.nature.com/6mtz2d (2014).
Geurts, A. M. Science. 325, 433 (2009).
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E.L. and F.U. are employees of Sangamo BioSciences, Inc.
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Lanphier, E., Urnov, F., Haecker, S. et al. Don’t edit the human germ line. Nature 519, 410–411 (2015). https://doi.org/10.1038/519410a
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DOI: https://doi.org/10.1038/519410a
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