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CRISPR, the disruptor

Nature volume 522, pages 20–24 (2015)Cite this article

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08 June 2015 An earlier version of the graphic entitled ‘A brief history of CRISPR' had an ambiguous entry for June 2012. The text has now been made clearer.

A Correction to this article was published on 10 June 2015

A powerful gene-editing technology is the biggest game changer to hit biology since PCR. But with its huge potential come pressing concerns.

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Change history

  • 08 June 2015

    An earlier version of the graphic entitled ‘A brief history of CRISPR' had an ambiguous entry for June 2012. The text has now been made clearer.

References

  1. Jinek, M. et al. Science 337, 816–821 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Liang, P. et al. Protein Cell 6, 363–372 (2015).

    Article  CAS  Google Scholar 

  3. Vyas, V. K., Barrasa, M. I. & Fink, G. R. Sci. Adv. 1, e1500248 (2015).

    Article  ADS  Google Scholar 

  4. Maddalo, D. et al. Nature 516, 423–427 (2014).

    Article  ADS  CAS  Google Scholar 

  5. Yin, H. et al. Nature Biotechnol. 32, 551–553 (2014).

    Article  CAS  Google Scholar 

  6. Oye, K. A. et al. Science 345, 626–628 (2014).

    Article  ADS  CAS  Google Scholar 

  7. Gantz, V. M. & Bier, E. Science 348, 442–444 (2015).

    Article  ADS  CAS  Google Scholar 

  8. Ishino, Y., Shinagawa, H., Makino, K., Amemura, M. & Nakata, A. J. Bacteriol. 169, 5429–5433 (1987).

    Article  CAS  Google Scholar 

  9. Mojica, F. J., Ferrer, C., Juez, G. & Rodríguez-Valera, F. Mol. Microbiol. 17, 85–93 (1995).

    Article  CAS  Google Scholar 

  10. Barrangou, R. et al. Science 315, 1709–1712 (2007).

    Article  ADS  CAS  Google Scholar 

  11. Cong, L. et al. Science 339, 819–823 (2013).

    Article  ADS  CAS  Google Scholar 

  12. Mali, P. et al. Science 339, 823–826 (2013).

    Article  ADS  CAS  Google Scholar 

  13. Jinek, M. et al. eLife 2, e00471 (2013).

    Article  Google Scholar 

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Authors
  1. Heidi Ledford
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US science academies take on human-genome editing 2015-May-18

Regulate gene editing in wild animals 2015-May-12

Embryo editing sparks epic debate 2015-Apr-29

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Mini enzyme moves gene editing closer to the clinic 2015-Apr-01

Nature special: CRISPR

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Video: Genome Editing with CRISPR-Cas9

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Ledford, H. CRISPR, the disruptor. Nature 522, 20–24 (2015). https://doi.org/10.1038/522020a

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