Abstract
Design
A multi-centre, placebo-controlled, double-blind, randomised clinical trial involving 983 adults (aged 18-80 years old).
Intervention
The test group received chlorhexidine diacetate 10% weight per volume (w/v) dental coating and the control group received a placebo coating. Coatings were applied weekly for four weeks and a fifth time six months later.
Outcome measure
The Pitts and Fyffe taxonomy1 was used to measure caries progression or reversal, which identifies three stages of lesion on coronal surfaces. The primary outcome was the total net increment in D1-2FS; secondary outcomes included the cumulative net D1-2FS increment and the total crude D1-2FS increment and the cumulative crude D1-2FS increment.
Results
No significant difference was seen between the treatment and placebo groups over a 13 month study period.
Conclusions
Ten percent chlorhexidine diacetate coating did not show a reduction in caries in an adult population.
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References
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Vollmer WM, Papas AS, Bader JD, Maupome G, Gullion CM, Hollis JF, Snyder JJ, Fellows JL, Laws RL, White BA . Design of the Prevention of Adult Caries Study (PACS): A randomized clinical trial assessing the effect of a chlorhexidine dental coating for the prevention of adult caries. BMC Oral Health 2010; 10: 23
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Authors and Affiliations
Additional information
Address for correspondence William.vollmer, Kaiser Permanente Center for Health Research, 3800 North Interstate Avenue, Portland, OR 97227, USA. Email william.vollmer@kpchr.org
Papas AS, Vollmer WM, Gullion CM, et al PACS Collaborative Group. Efficacy of chlorhexidine varnish for the prevention of adult caries: a randomized trial. J Dent Res. 2012; 91: 150–155. Epub 2011 Dec 7.
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O'Keefe, E. 10% chlorhexidine varnish did not reduce caries in an adult population. Evid Based Dent 13, 45 (2012). https://doi.org/10.1038/sj.ebd.6400857
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DOI: https://doi.org/10.1038/sj.ebd.6400857
