Abstract
Purpose To evaluate the results of patching treatment in children with macular retinoblastoma in one eye.
Methods Fifteen children affected by macular retinoblastoma received instructions for patching treatment for amblyopia. Data were collected on age at diagnosis of the tumor, presence of unilateral or bilateral disease, area of posterior pole involvement by the scar of the regressed tumor and its relationship to the fovea; and the onset, duration, and compliance of patching. The visual acuities recorded were expressed in logMAR (logarithm minimum angle of resolution) equivalents.
Results Twelve children (80%) had bilateral retinoblastoma with the macular involved in one eye and three children had unilateral macular tumors. The median age at which patching was initiated was 15 months (range 4–36). Compliance to patching was good in 80% of children, with a median duration of 4 h (range 0.5–8) per day, 7 days per week, with total occlusion of the better eye. The median percentage of posterior pole involvement was 34% (range 11–100%). Eighty percent of children had some improvement in their visual acuity, and of the children in whom final logMAR acuity was recorded, 73% had an acuity of 1.0 logMAR or better and 53% an acuity of 0.5 logMAR or better after patching. There was no evidence of association between age of patient, sex, duration of patching, or percentage of posterior pole involvement and the improvement in visual acuity.
Conclusions In spite of the macular involvement of eyes with retinoblastoma, some visual recovery was achieved in 80% of children. Hence a trial of patching therapy is recommended for all children with involvement of the macula by retinoblastoma.
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References
Murphree AL . Retinoblastoma. In: Traboulsi E (ed). Genetic Diseases of the Eye Oxford University Press: Oxford 1998 813–849
Sanders BM, Draper GJ, Kingston JE . Retinoblastoma in Great Britain 1969–1980: incidence treatment and survival. Br J Ophthalmol 1988; 72: 576–583
Migdal C . Bilateral retinoblastoma: the prognosis for vision. Br J Ophthalmol 1983; 67: 592–595
Gallie BL, Budning A, DeBoer G, Thiessen JJ, Koren G, Verjee Z et al. Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy. Arch Ophthalmol 1996; 114: 1321–1328
Murphree AL, Villablanca JG, Deegan WF, Sato JK, Malogolowkin M, Fisher A et al. Chemotherapy plus local treatment in the management of intraocular retinoblastoma. Arch Ophthalmol 1996; 114: 1348–1356
Kingston JE, Hungerford JL, Madreperla SA, Plowman PN . Results of combined chemotherapy and radiotherapy for advanced intraocular retinoblastoma. Arch Ophthalmol 1996; 114: 1339–1343
Lam BL, Judisch GF, Sobol WM, Blodi CF . Visual prognosis in macular retinoblastomas. Am J Ophthalmol 1990; 110: 229–232
Weiss AV, Karr DJ, Kalina RE, Lindsley KL, Pendergrass TW . Visual outcomes of macular retinoblastoma after external beam radiation therapy. Ophthalmology 1994; 101: 1244–1249
Hall LS, Ceisler E, Abramson DH . Visual outcomes in children with bilateral retinoblastoma. JAAPOS 1999; 3: 138–142
Lueder GT, Goyal R . Visual function after laser hyperthermia and chemotherapy for macular retinoblastoma. Am J Ophthalmol 1996; 121: 582–584
Lang LLH, Lambert SR . Reappraisal of occlusion therapy for severe structural abnormalities of the optic disc and macula. J Pediatr Ophthalmol Strabismus 1995; 32: 37–41
Kushner BJ . Functional amblyopia associated with organic ocular disease. Am J Ophthalmol 1981; 91: 39–45
Simons Kurt, Preslan M . Natural history of amblyopia untreated owing to lack of compliance. Br J Ophthalmol 1999; 83: 582–587
Holbeck S, Ehlers N . Long term visual results in eyes cured for retinoblastoma by radiation. Acta Ophthalmol 1989; 67: 560
Acknowledgements
This paper was prepared with assistance of Editorial Services, The Hospital for Sick Children, Toronto, Canada. P Watts was supported by Pharmacia Upjohn.
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Watts, P., Westall, C., Colpa, L. et al. Visual results in children treated for macular retinoblastoma. Eye 16, 75–80 (2002). https://doi.org/10.1038/sj.eye.6700070
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DOI: https://doi.org/10.1038/sj.eye.6700070
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