Abstract
Retinal detachment continues to be a significant cause of visual impairment, either through the direct effects of macular detachment or through secondary complications such as subretinal fibrosis or proliferative vitreoretinopathy. Animal models can provide us with an understanding of the cellular mechanisms at work that account for the retinopathy induced by detachment and for the generation of secondary effects. As we understand the mechanisms involved, animal models can also provide us with opportunities to test therapeutic agents that may reduce the damaging effects of detachment or improve the outcome of reattachment surgery. They may also reveal information of use to understanding other causes of blindness rooted in retinal defects or injuries. Understanding the effects of detachment (and reattachment) are likely to become even more important as surgeons gain skills in subretinal surgical techniques and macular translocation, both of which will generate short-lived detachments. Here we discuss the fundamental events that occur after detachment, present changes associated with reattachment, and discuss retinal changes that may affect the return of vision.
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References
Steinberg RH, Reid M, Lacy PL . 1973. The distribution of rods and cones in the retina of the cat (Felis domesticus). J Comp Neurol 1973; 148: 229–248
Anderson DH, Guérin CJ, Erickson PA, Stern WH, Fisher SK . Morphological recovery in the reattached retina. Invest Ophthalmol Vis Sci 1986; 27: 168–183
Ohkuma M . Transmission and scanning electron microscopic observations of the experimentally detached retina in the rabbit. I. Early changes of the detached retina. Acta Societatis Ophthalmologicae Japonicae 1972; 76: 303–315
Ozaki S, Radeke MJ, Anderson DH . Rapid upregulation of fibroblast growth factor receptor 1 (flg) by rat photoreceptor cells after injury. Invest Ophthalmol Vis Sci 2000; 41: 568–579
Kroll AJ, Machemer R . Experimental retinal detachment and reattachment in the rhesus monkey. Am J Ophthalmol 1969; 68: 58–77
Guérin CJ, Anderson DH, Fisher SK . Retinal reattachment of the primate macula; photoreceptor recovery after short term detachment. Invest Ophthalmol Vis Sci 1989; 30: 1708–1725
Mervin K, Valter K, Maslim J, Lewis GP, Fisher S, Stone J . Limiting photoreceptor death and deconstruction during experimental retinal detachment: the value of oxygen supplementation. Am J Ophthalmol 1999; 128: 155–164
Lewis GP, Mervin K, Valter K, Maslim J, Kappel PJ, Stone J, Fisher S . Limiting the proliferation and reactivity of retinal Müller cells during experimental retinal detachment: the value of oxygen supplementation. Am J Ophthalmol 1999; 128: 165–172
Lewis GP, Linberg KA, Geller SF, Guérin CJ, Fisher SK . Effects of the neurotrophin brain-derived neurotrophic factor in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 1999; 40: 1530–1544
Kroll AJ, Machemer R . Experimental retinal detachment in the owl monkey. V. Electron microscopy of the reattached retina. Am J Ophthal 1969; 67: 117–130
Fisher SK, Anderson DH . Cellular effects of detachment on the neural retina and the retinal pigment epithelium In: SJ Ryan, CP Wilkinson (eds) Retina, Vol 3. Surgical Retina Mosby: St Louis 2001 pp 1961–1986
Guérin CJ, Lewis GP, Fisher SK, Anderson DH . Recovery of photoreceptor outer segment length and analysis of membrane assembly rates in regenerating primate photoreceptor outer segments. Invest Ophthalmol Vis Sci 1993; 34: 175–183
Cook B, Lewis GP, Fisher SK, Adler R . Apoptotic photoreceptor degeneration in experimental retinal detachment. Invest Ophthalmol Vis Sci 1995; 36: 990–996
Chang CJ, Lai WW, Edward DP, Tso MO . Apoptotic photoreceptor cell death after traumatic retinal detachment in humans. Arch Ophthalmol 1995; 113: 880–886
Erickson P, Fisher S, Anderson D, Stern W, Borgula G . Retinal detachment in the cat: the outer nuclear and outer plexiform layers. Invest Ophthalmol Vis Sci 1983; 24: 927–942
Wilson DJ, Green WR . Histopathologic study of the effect of retinal detachment surgery on 49 eyes obtained post mortem. Am J Ophthalmol 1987; 103: 167–179
Linberg KA, Lewis GP, Shaaw C, Rex T, Fisher SK . Distribution of S- and M-cones in normal and experimentally detached cat retina. J Comp Neurol 2001; 430: 343–356
John SK, Smith JE, Aguirre GD, Milam AH . Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa. Mol Vis 2000; 6: 204–215
Jacobs GH, Calderone JB, Sakai T, Lewis GP, Fisher SK . An animal model for studying cone function in retinal detachment. Documenta Ophthalmological 2002; 104: 119–132
Sakai T, Lewis GP, Linberg KA, Fisher SK . Hyperoxia can rescue cone-dominant retina from the effects of detachment. Invest Ophthalmol Vis Sci 2001; 42: 3264–3273
Fariss RN, Molday RS, Fisher SK, Matsumoto B . Evidence from normal and degenerating photoreceptors that two outer segment integral membrane proteins have separate transport pathways. J Comp Neurol 1997; 387: 148–156
Lewis GP, Linberg A, Fisher SK . Neurite outgrowth from bipolar and horizontal cells after experimental retinal detachment. Invest Ophthalmol Vis Sci 1998; 39: 424–434
Coblentz FF, Lewis GP, Radeke MJ, Fisher SK . Identification of changes in ganglion cells and horizontal cells folowing retinal detachment. Invest Ophthalmol Vis Sci 2001; 42: S445
Fisher SK, Erickson PA, Lewis GP, Anderson DH . Intraretinal proliferation induced by retinal detachment. Invest Ophthalmol Vis Sci 1991; 32: 1739–1748
Geller SC, Lewis GP, Anderson DH, Fisher SK . The use of the MIB-1 antibody for detecting proliferating cells in the retina. Invest Ophthalmol Vis Sci 1995; 36: 737–743
Geller SF, Lewis GP, Fisher SK . FGFR1, Signaling, and AP-1 expression after retinal detachment: reactive Müller and RPE cells. Invest Ophthalmol Vis Sci 2001; 42: 1363–1369
Lewis GP, Erickson PA, Guérin CJ, Anderson DH, Fisher SK . Changes in the expression of specific Müller cell proteins during long-term retinal detachment. Exp Eye Res 1989; 49: 93–111
Lewis GP, Fisher SK . Müller cell outgrowth after retinal detachment: association with cone photoreceptors. Invest Ophthalmol Vis Sci 2000; 41: 1542–1545
Lewis GP, Charteris DG, Sethi CS, Leitner WP, Linberg KA, Fisher SK . The ability of rapid retinal reattachment to stop or reverse the cellular and molecular events initiated by detachment. Invest Ophthalmol Vis Sci 2002; 43 (in press)
Acknowledgements
This work was supported by grant EY-00888 from the National Eye Institute of the National Institutes of Health; Special Trustees of Moorfields Eye Hospital; The Royal College of Surgeons of Edinburgh & The Royal Blind Asylum/Scottish National Institution for the War Blinded. CS Sethi is a Medical Research Council Clinical Training Fellow. This material were presented at the 31st Cambridge Ophthalmological Symposium, Cambridge, UK.
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Lewis, G., Charteris, D., Sethi, C. et al. Animal models of retinal detachment and reattachment: identifying cellular events that may affect visual recovery. Eye 16, 375–387 (2002). https://doi.org/10.1038/sj.eye.6700202
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DOI: https://doi.org/10.1038/sj.eye.6700202
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