Abstract
Idiopathic orbital inflammation (IOI) is a well-recognised pathological process usually confined to the orbit. It is an orbital mass lesion characterised by infiltration of soft tissues by inflammatory cells and fibrous tissue. It is essentially a diagnosis of exclusion. Extraorbital extension (EOE) is rare and, to the best of the authors' knowledge, inclusive of our series, there have been 22 cases of IOI with EOE reported in the literature. We describe four patients with IOI with EOE—their presentation, histopathological findings and management strategies. Histopathology of three patients revealed sclerosing and one had a nonspecific variant of IOI. In our series, all four patients required additional immunosuppression. Hence, corticosteroid therapy often needs to be supplemented by radiotherapy and/or immunosuppressive therapy.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Clifton A, Borgstein R, Moseley I, Kendall B, Shaw P . Intracranial extension of orbital pseudotumour. Clin Radiol 1992; 45: 23–26.
De Jesus O, Inserni J, Gonzalez A, Colon L . Idiopathic orbital inflammation with intracranial extension. Case report. J Neurosurg 1996; 85: 510–513.
Cruz A, Akaishi P, Chahud F, Elias J . Sclerosing inflammation in the orbit and in the pterygopalatine and infratemporal fossae. Ophthalmic Plastic Reconstr Surg 2003; 19 (3): 201–206.
Norman E, Charles C, Turbin R . Bilateral sclerosing orbital pseudotumour with intracranial spread. Arch Ophthalmol 2003; 121 (3): 412–413.
Kaye A, Hahn J, Crociun A, Hanson M, Berlin J, Tubbs R . Intracranial extension of inflammatory pseudotumour of the orbit. Case report. J Neurosurg 1984; 60: 625–629.
Bencherif B, Zouaoui A, Chedid G, Kujas M, Van Effenterre R, Marsault C . Intracranial extension of the idiopathic orbital inflammatory pseudotumour. Am J Neuroradiol 1993; 14: 181–184.
Soares D, Crandon I, Char D, Carpenter R . Orbital pseudotmour with intracranial extension. A case report. West Indian Med J 1998; 47 (2): 68–71.
Noble S, Chandler W, Lloyd R . Intracranial extension of orbital pseudotumor: A case report. Neurosurgery 1986; 18 (6): 798–801.
Frohman L, Kupersmith M, Lnag J, Reede D, Bergeron T, Aleksic S et al. Intracranial extension and bone destruction in orbital pseudotumour. Arch Ophthalmol 1986; 104: 380–384.
Satorre J, Antle M, O'Sullivan R, White V, Nugent K, Rootman J . Orbital lesions with granulomatous inflammation. Can J Ophthalmol 1991; 26 (4): 174–195.
Weissler M, Miller E, Fortune M . Sclerosing orbital pseudotumor: a unique clinicopathologic entity. Ann Otol Rhinol Laryngol 1989; 98: 496–501.
Aylward GW, Sullivan TJ, Garner I, Moseley I, Wright JE . Orbital involvement in multifocal fibrosclerosis. Br J Ophthamol 1995; 79: 246–249.
Richards A, Skalka H, Roberts F, Flint A . Pseudotumor of the orbit and retroperitoneal fibrosis. Arch Ophthalmol 1980; 98: 1617–1620.
Rootman J . Why ‘orbital pseudotumour’ is no longer a useful concept. Br J Ophthalmol 1998; 82: 339–340.
Mombaerts I, Goldschmeding R, Schlingemann RO, Koornneef L . What is orbital pseudotumor? Surv Ophthalmol 1996; 41 (1): 66–78 (Review) (139 refs).
Eagle K, King A, Fisher C, Souhami R . Cyclophosphamide induced remission in relapsed, progressive idiopathic orbital inflammation (‘Pseudotumour’). Clin Oncol 1995; 7: 402–404.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Zborowska, B., Ghabrial, R., Selva, D. et al. Idiopathic orbital inflammation with extraorbital extension: case series and review. Eye 20, 107–113 (2006). https://doi.org/10.1038/sj.eye.6701780
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/sj.eye.6701780
Keywords
This article is cited by
-
Orbital inflammatory pseudotumor: new advances in diagnosis, pathogenesis, and treatment
European Journal of Medical Research (2023)
-
Intracranial extension of orbital inflammatory pseudotumor: a case report and literature review
BMC Neurology (2016)
-
Suspected idiopathic sclerosing orbital inflammation presenting as immunoglobulin G4-related disease: a case report
Journal of Medical Case Reports (2011)
-
Orbital myositis: Diagnosis and management
Current Allergy and Asthma Reports (2009)
-
Orbital inflammatory disease: a diagnostic and therapeutic challenge
Eye (2006)
