Figure 2 | Eye

Figure 2

From: Expression of the PDE5 enzyme on human retinal tissue: new aspects of PDE5 inhibitors ocular side effects

Figure 2

Western blot for both PDE6 and PDE5 (a and b) demonstrating the presence of the two proteins in human retinal tissues, testis, and corpus cavernosum (1: retina, 2: testis, 3: spermatozoa, 4: skin, 5: corpus cavernosum). The immunohistochemical analysis (c and d) clearly revealed that the PDE6 enzyme is expressed on the photoreceptor layer both on rods and cones. The PDE5 has been localized on endothelial and smooth muscle cells of the vascular wall (retina and choroids vessels), on ganglion cells (III neuron) and bipolar cells (II neuron). C, choroids; P, photoreceptors layer; ON, outer nuclear layer; IN, inner nuclear layer; GL, ganglion cell layer. PDE5, phosphodiesterase type-5; PDE6, phosphodiesterase type-6.

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