Abstract
Aim:
To examine the biological consequences and demographic factors that might affect the pharmacokinetics of vitamin D3 after a single high dose intervention in a young Chinese population with vitamin D insufficiency status.
Methods:
A total of 28 young subjects (25 to 35 years old) with vitamin D insufficiency status [serum 25(OH)D <30 ng/mL] was recruited in Shanghai, China. The subjects were orally administered a single high dose of vitamin D3 (300 000 IU). Baseline characteristics and blood samples were collected at d 0, 1, 2, 3, 7, 28, 56, 84 and 112 after the intervention. The blood biomarker levels were determined with standardized methods.
Results:
The intervention markedly increased the blood 25(OH)D3 levels within the first five days (mean Tmax=5.1±2.1 d) and sustained an optimal circulating level of 25(OH)D3 (≥30 ng/mL) for 56 d. After the intervention, body weight and baseline 25(OH)D3 levels were significantly correlated with circulating 25(OH)D3 levels. No adverse events and no consistently significant changes in serum calcium, creatinine, glucose, parathyroid hormone, vitamin D binding protein, or the urinary calcium/reatinine ratio were observed. However, there was a significant increase in phosphorus after the vitamin D3 intervention. Total cholesterol and triglyceride levels were decreased at the end of the trial.
Conclusion:
The pharmacokinetics of vitamin D after intervention were influenced by baseline 25(OH)D3 levels and the body weight of the subjects. The results suggest that a single high oral vitamin D3 intervention is safe and efficient for improving the vitamin D status of young Chinese people with vitamin D insufficiency.
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Acknowledgements
We thank Dr Donald HILL for his assistance in manuscript preparation. This work was supported by grants from the Ministry of Science and Technology of China (2014AA020524), the National Natural Science Foundation of China (91529305, 81302507, 81573161, 81427805, 81302809, and 31401611), the CAS/SAFEA International Partnership Program for Creative Research Teams of the Chinese Academy of Sciences, the Science and Technology Commission of Shanghai Municipality (14391901800 and 13ZR1446500), and the Key Laboratory of Food Safety Research of Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.
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Supplementary Tables are available on the website of Acta Pharmacologica Sinica.
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Supplementary Table S1
Univariant analyses for the correlation between the demographic factors and baseline blood parameters and the circulating 25(OH)D3 levels after the intervention. (DOC 44 kb)
Supplementary Table S2
Correlation between the AUC0∼∞ (ng*d/mL) and the demographic and genetic factors. (DOC 33 kb)
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Chen, Pz., Li, M., Duan, Xh. et al. Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3. Acta Pharmacol Sin 37, 1509–1515 (2016). https://doi.org/10.1038/aps.2016.82
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DOI: https://doi.org/10.1038/aps.2016.82
