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Mycobacterium tuberculosis infection: a rare late complication after cord blood hematopoietic SCT

Bone Marrow Transplantation volume 43, pages 667–668 (2009)Cite this article

The use of cord blood units (CBU) as a source of hematopoietic stem cells (HSC) for transplant has increased during the last few years.1 The main obstacle for the use of CB for adult transplantation is the proportionally small content of HSC, which leads to delayed engraftment, relatively slower immunological recovery and higher incidence of graft failure when compared with other HSC sources. The end result is a higher incidence of TRM secondary to infections.1, 2

Mycobacterial tuberculosis (MT) infections are rare among hematopoietic SCT (HSCT) patients, but are more likely to affect patients from countries with high incidence and prevalence of tuberculosis.3, 4, 5, 6, 7 Here, we discuss a case of MT in a CB transplant recipient coming from an MT endemic area, and who received his transplant in the United States.

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References

  1. Gratwohl A, Baldomero H, Frauendorfer K, Rocha V, Apperley J, Niederwieser D et al. The EBMT activity survey 2006 on hematopoietic stem cell transplantation: focus on the use of cord blood products. Bone Marrow Transplant 2008; 41: 687–705.

    Article  CAS  Google Scholar 

  2. Rocha V, Garnier F, Ionescu I, Gluckman E, Eurocord and European Blood and Marrow Transplant Group. Hematopoietic stem-cell transplantation using umbilical-cord blood cells. Rev Invest Clin 2005; 57: 314–323.

    PubMed  Google Scholar 

  3. George B, Mathews V, Srivastava A, Chandy M . Infections among allogeneic bone marrow transplant recipients in India. Bone Marrow Transplant 2004; 33: 311–315.

    Article  CAS  Google Scholar 

  4. Aljurf M, Gyger M, Alrajhi A, Sahovic E, Chaudhri N, Musa M et al. Mycobacterium tuberculosis infection in allogeneic bone marrow transplantation patients. Bone Marrow Transplant 1999; 24: 551–554.

    Article  CAS  Google Scholar 

  5. Roy V, Weisdorf D . Mycobacterial infections following bone marrow transplantation: a 20 year retrospective review. Bone Marrow Transplant 1997; 19: 467–470.

    Article  CAS  Google Scholar 

  6. Yuen KY, Woo PC . Tuberculosis in blood and marrow transplant recipients. Hematol Oncol 2002; 20: 51–62.

    Article  CAS  Google Scholar 

  7. Navari RM, Sullivan KM, Springmeyer SC, Siegel MS, Meyers JD, Buckner CD et al. Mycobacterial infections in marrow transplant patients. Transplantation 1983; 36: 509–513.

    Article  CAS  Google Scholar 

  8. de Lima M, McMannis J, Gee A, Komanduri K, Couriel D, Andersson BS et al. Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial. Bone Marrow Transplant 2008; 41: 771–778.

    Article  CAS  Google Scholar 

  9. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Guia de vigilância epidemiológica. Ministério da Saúde: Brasília, 2005. Available at http://bvsms.saude.gov.br/bvs/publicacoes/Guia_Vig_Epid_novo2.pdf. Accessed in 2008 (September 15).

  10. Cordonnier C, Martino R, Trabasso P, Held TK, Akan H, Ward MS et al. Mycobacterial infection: a difficult and late diagnosis in stem cell transplant recipients. Clin Infect Dis 2004; 38: 1229–1236.

    Article  CAS  Google Scholar 

  11. Maeda T, Kusumi E, Kami M, Kawabata M, Le Pavoux A, Hara S et al. Disseminated tuberculosis following reduced-intensity cord blood transplantation for adult patients with hematological diseases. Bone Marrow Transplant 2005; 35: 91–97.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Bone Marrow Transplantation Division, Albert Einstein Hospital, São Paulo, Brazil

    R A De Assis, F R Kerbauy, M Rodrigues, F S Seguro, L F C Aranha & N Hamerschlak

  2. Department of Lymphoma, M.D. Anderson Cancer Center, Houston, TX, USA

    L Fayad

  3. Department of Stem Cell Transplantation and Cell Therapy, M.D. Anderson Cancer Center, Houston, TX, USA

    E J Shpall & M de Lima

Authors
  1. R A De Assis
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  2. F R Kerbauy
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  3. M Rodrigues
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  4. F S Seguro
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  5. L F C Aranha
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  6. L Fayad
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  7. E J Shpall
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  8. M de Lima
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  9. N Hamerschlak
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Correspondence to N Hamerschlak.

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De Assis, R., Kerbauy, F., Rodrigues, M. et al. Mycobacterium tuberculosis infection: a rare late complication after cord blood hematopoietic SCT. Bone Marrow Transplant 43, 667–668 (2009). https://doi.org/10.1038/bmt.2008.379

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