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Pandemic influenza A H1N1/09 virus infection in hematopoietic SCT recipient

Bone Marrow Transplantation volume 46, pages 467–468 (2011)Cite this article

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In April 2009, the first cases of the novel influenza A H1N1 virus infection were reported in Mexico.1 As of 27 October 2009, the novel influenza H1N1 virus had caused at least 5642 deaths reported worldwide.1 The pandemic influenza H1N1/09 virus infection was considered widespread in Brazil on 16 July 2009 and after 2 months, there were 9249 confirmed cases, including 699 deaths.2

Clinical presentation may range from mild symptoms to cases of severe clinical presentation and death due to pneumonia and respiratory failure. Defined high-risk groups are thought to be similar to those for seasonal influenza, including young children and elderly patients, pregnant women and patients with chronic medical conditions, especially immunocompromised hosts.3 Immunosuppressed patients with influenza virus infection can shed virus for prolonged periods, increasing the chances for development of drug resistance. Recently, evidence of resistance to the antiviral medication oseltamivir was detected in two severely immunosuppressed patients with novel influenza A (H1N1) virus infection and prolonged shedding was observed.4

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References

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Authors and Affiliations

  1. Hospital Sírio-Libanês, Sao Paulo, Brazil

    D A Bastos & Y Novis

  2. BMT Unit, Hospital Sírio-Libanês, Sao Paulo, Brazil

    C A Rodrigues & P Patah

  3. Division of Clinical Immunology and Allergy, Medical School, University of Sao Paulo, Sao Paulo, Brazil

    E G Kallas

  4. Eurocord/Saint-Louis Hospital, Paris, France

    V Rocha

Authors
  1. D A Bastos
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  2. C A Rodrigues
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  3. P Patah
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  4. E G Kallas
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  6. Y Novis
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Correspondence to D A Bastos.

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Bastos, D., Rodrigues, C., Patah, P. et al. Pandemic influenza A H1N1/09 virus infection in hematopoietic SCT recipient. Bone Marrow Transplant 46, 467–468 (2011). https://doi.org/10.1038/bmt.2010.133

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