Brdm2—an aberrant hypomorphic p63 allele

Dear Editor,

In response to our recent report on the Brdm2 mouse model for p63 function,¹ Mikkola et al.² raise concerns on three of our statements: (1) they maintain their initial claim that no functional p63 protein of any kind is synthesized in mice homozygous for the Brdm2 allele; (2) they report the occurrence of spontaneous wild-type allelic reversions in these mice, leading to patches of completely normal epidermis, and propose that these normal reverted skin patches are in fact the multilayered epithelia we described; and (3) they insist that the Brdm2 allele is phenotypically indistinguishable from a global p63 knockout.

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account

Continue with Google

Continue with ORCiD