Neutralizing gp130 interferes with endothelial-mediated effects on glioblastoma stem-like cells

Dear Editor,

Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults. The aggressiveness of the disease partly relies on a subpopulation of tumor cells, termed as glioblastoma stem-like cells (GSCs) with a phenotype similar to that of normal neural stem cells such as multipotency and the ability to self-renewal.^{1, 2} GSCs have been implicated in tumor initiation and growth, resistance to therapies, and recurrence.^{1, 2, 3} Additionally, it has been reported that GSCs reside in vascular niches in close contact with brain endothelial cells. These niches may regulate GSC self-renewal, determine cell fate, and protect these cells from chemo- and radiation therapies.^{3, 4} Accordingly, the localization of GSCs in close proximity to endothelial cells facilitates reciprocal communication, allowing notably the vascular niche to provide paracrine factors essential to maintain GSCs.^{4, 5}

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