Figure 7 | Cell Death & Disease

Figure 7

From: Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo

Figure 7

SeC enhances AF-induced growth inhibition of tumor xenografts through targeting TrxR1 in vivo. Combined treatment inhibits tumor volume (a, b) and tumor weight (c) of A549 human lung adenocarcinoma xenografts in nude mice, but do not affect body weight (d) of mice. (e) Combined treatment activates caspase in vivo. (f) Combined treatment triggers PARP clevage and inactivation of TrxR1 in vivo. (g) Staining of tumor xenografts by hematoxylin and eosin and IHC method

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