Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Jackowski S, Rock CO . Regulation of coenzyme A biosynthesis. J Bacteriol 1981; 148:926–932.
Rock CO, Calder RB, Karim MA, Jackowski S . Pantothenate kinase regulation of the intracellular concentration of coenzyme A. J Biol Chem 2000; 275:1377–1383.
Zhao JY, Xiong MM, Huang W, et al. An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese. J Mol Med 2005; 83:209–215.
Li Y, Wu GD, Zuo J, et al. Screening susceptibility genes of type 2 diabetes in Chinese population by single nucleotide polymorphism analysis. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005; 27:274–279.
Li Y, Wu G, Zuo J, Gao J, Chang Y, Fang FD . Genetic variations of the CDC2L2 gene are associated with type 2 diabetes in a Han Chinese cohort. Diabetes Metab Res Rev 2007; 23:455–461.
Chang YS, Li YF, Zuo J, Fang FD . A novel gene involved in blood glucose regulation. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2002; 24:466–470.
Li YF, Chang YS, Zhang LF, et al. High glucose upregulates pantothenate kinase4 (PANK4) thus affectes M2-type pyrvate kinase (Pkm2). Mol Cell Biochem 2005; 277:117–125.
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC . Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52:102–110.
Zhang YM, Chohnan S, Virga KG, et al. Chemical Knockout of Pantothenate Kinase Reveals the Metabolic and Genetic Program Responsible for Hepatic CoenzymeA Homeostasis. Chem & Biol 2007; 14:291–302.
Afshar K, Gonczy P, DiNardo S, Wasserman SA . Fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster. Genetics 2001; 157:1267–1276.
Acknowledgements
We are indebted to Dr Jin Ming Gao for critical reading of this manuscript. This work was supported by the National Basic Research Program of China (2004CB518602 and 2006CB503909), the National Natural Science Foundation of China (30471930) and the Beijing Natural Science Foundation (5072042).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Xiang, R., Yang, Y., Zuo, J. et al. PanK4 inhibits pancreatic β-cell apoptosis by decreasing the transcriptional level of pro-caspase-9. Cell Res 17, 966–968 (2007). https://doi.org/10.1038/cr.2007.93
Published:
Issue date:
DOI: https://doi.org/10.1038/cr.2007.93