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References
Bilder D . Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev 2004; 18:1909–1925.
Bilder D, Li M, Perrimon N . Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 2000; 289:113–116.
Igaki T, Pagliarini RA, Xu T . Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol 2006; 16:1139–1146.
Uhlirova M, Bohmann D . JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J 2006; 25:5294–5304.
Martin-Blanco E, Gampel A, Ring J, et al. puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev 1998; 12:557–570.
Brand AH, Perrimon N . Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993; 118:401–415.
Struhl G, Basler K . Organizing activity of wingless protein in Drosophila. Cell 1993; 72:527–540.
Glise B, Bourbon H, Noselli S . hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 1995; 83:451–461.
Wagner EF, Nebreda AR . Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 2009; 9:537–549.
Wodarz A, Nathke I . Cell polarity in development and cancer. Nat Cell Biol 2007; 9:1016–1024.
Acknowledgements
We thank Michel Sémériva (IBDML, France), Fumio Matsuzaki (RIKEN CDB, Japan), Michael J Galko (UT MD Anderson Cancer Center, USA), Enrique MartÃn-Blanco (Instituto de Biologia Molecular de Barcelona, Spain), Dirk Bohmann (University of Rochester, USA), Kyung-Ok Cho (Baylor College of Medicine, USA), the Bloomington Drosophila Stock Center, NIG-FLY (Japan), and the Developmental Studies Hybridoma Bank for providing fly strains and antibodies. We also thank Wenjuan Xiang and Wentian Gu in ML's Lab for the technical assistance. This work was supported by National Natural Science Foundation of China (30470890), National Basic Research Program of China (2007CB914504, 2007CB947301), the Shanghai Pujiang Program (05PJ14075) and Shanghai Leading Academic Discipline Project (B205).
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Figure S1
JNK activation is required for both tumor growth and invasion of lgl imaginal discs. (PDF 133 kb)
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Zhu, M., Xin, T., Weng, S. et al. Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs. Cell Res 20, 242–245 (2010). https://doi.org/10.1038/cr.2010.2
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DOI: https://doi.org/10.1038/cr.2010.2
