Abstract
In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a large sample of PD cases and controls from the Netherlands. After quality control (QC), a total of 514 799 SNPs genotyped in 772 PD cases and 2024 controls were included in our analyses. Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P=1.63 × 10−5, OR=1.325 and BST1, rs12502586: P=1.63 × 10−3, OR=1.337). Within SNCA, two independent signals in two different linkage disequilibrium (LD) blocks in the 3′ and 5′ ends of the gene were detected. Besides, post-hoc analysis confirmed GAK/DGKQ, HLA and MAPT as PD risk loci among the Dutch (GAK/DGKQ, rs2242235: P=1.22 × 10−4, OR=1.51; HLA, rs4248166: P=4.39 × 10−5, OR=1.36; and MAPT, rs3785880: P=1.9 × 10−3, OR=1.19).
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Acknowledgements
We thank the subjects involved in this study for making this work possible. We also want to thank the Hersenstichting Nederland (http://www.hersenstichting.nl), the Neuroscience Campus Amsterdam and the section of Medical genomics (MGA) and the Intramural Research Program of the National Institute on Aging (National Institutes of Health, Department of Health and Human services; project number Z01 AG000949-04) for supporting in part the work presented here. Last, we would like to thank the Prinses Beatrix Fonds (http://www.prinsesbeatrixfonds.nl) for sponsoring this work.
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Simón-Sánchez, J., van Hilten, J., van de Warrenburg, B. et al. Genome-wide association study confirms extant PD risk loci among the Dutch. Eur J Hum Genet 19, 655–661 (2011). https://doi.org/10.1038/ejhg.2010.254
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DOI: https://doi.org/10.1038/ejhg.2010.254
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