Abstract
Genome-wide association studies have recently identified a cancer susceptibility locus at 10p12 mapping to MLLT10 associated with the onset of diverse tumors. We genotyped two tightly linked single-nucleotide polymorphisms (SNPs) at MLLT10 associated with meningioma (rs12770228) or ovarian cancer (rs1243180), and tested for associations among 295 meningioma cases, 606 glioma cases and 646 noncancer controls, all of European descent. The variant ‘A’ allele in MLLT10 rs12770228 was associated with an increased risk of meningioma (per allele odds ratio: 1.25; 95% confidence interval: 1.02, 1.53; P=0.031). Similar associations were observed for rs1243180. MLLT10 variants were unrelated to glioma. Functional investigation identified 22 candidate functional SNPs mapping to this region. The present study further validates 10p12 as a meningioma risk locus.
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Acknowledgements
Financial support was received from Public Health Service Grants R01CA116174 and R25T CA147832 (Dr Baskin) from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services and institutional funding from the Moffitt Cancer Center, Tampa, FL and the Vanderbilt-Ingram Comprehensive Cancer Center, Nashville, TN.
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Egan, K., Baskin, R., Nabors, L. et al. Brain tumor risk according to germ-line variation in the MLLT10 locus. Eur J Hum Genet 23, 132–134 (2015). https://doi.org/10.1038/ejhg.2014.70
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DOI: https://doi.org/10.1038/ejhg.2014.70
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