Abstract
Recent genome-wide association studies have identified common variants at multiple loci influencing lung cancer risk. To decipher the genetic basis of the association signals at 3q28, 5p15.33, 6p21.33, 9p21 and 12p13.33, we performed a meta-analysis of data from five genome-wide association studies in populations of European ancestry totalling 12 316 lung cancer cases and 16 831 controls using imputation to recover untyped genotypes. For four of the regions, it was possible to refine the association signal identifying a smaller region of interest likely to harbour the functional variant. Our analysis did not provide evidence that any of the associations at the loci being a consequence of synthetic associations rather than linkage disequilibrium with a common risk variant at these risk loci.
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Acknowledgements
This study was supported by grants from the National Institute of Health (NIH) (U19CA148127, 5R01CA055769, 5R01CA127219, 5R01CA133996, and 5R01CA121197, R01 CA111703 and UO1 CA63673, R01 CA092039, CA074386, CA092824, CA090578), Cancer Research UK (C1298/A8780, C1298/A8362), HEAL, Sanofi-Aventis, Institut National du Cancer, the European Community (Integrated Project DNA repair, LSHG-CT-2005-512113), the Norwegian Cancer Association, the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101), the Fred Hutchinson Cancer Research Center, an FP7 grant (REGPOT 245536), the Estonian Government (SF0180142s08), by EU RDF in the frame of Centre of Excellence in Genomics and Estoinian Research Infrastructure's Roadmap. We thank all individuals who participated in this study. The ICR study made use of data from the WTCCCII (http://www.wtccc.org.uk). We acknowledge the TCGA for their contribution of lung cancer genomic data to this study (Project Number 3230).
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Wang, Y., Wei, Y., Gaborieau, V. et al. Deciphering associations for lung cancer risk through imputation and analysis of 12 316 cases and 16 831 controls. Eur J Hum Genet 23, 1723–1728 (2015). https://doi.org/10.1038/ejhg.2015.48
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DOI: https://doi.org/10.1038/ejhg.2015.48
