Abstract
A form of experimental retinal vasculitis was induced in black hooded Lister rats by the inoculation of retinal S-antigen. Comparison of this disease with retinal vasculitis in man showed striking clinical, angiographic and pathological similarities. Clinically disc oedema, periphlebitis and retinal infiltrates were observed with corresponding leakage of dye on fluorescein angiography. Pathologically the disease showed perivascular lymphocytic infiltrates with focal photoreceptor necrosis. These characteristic features make this an ideal model for the study of the pathogenesis of retinal vasculitis in man.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Sanders MD : Retinal vasculitis: a review. J. Roy. Soc. Med. 1979; 72: 908–15.
Dumonde DC, Kasp E, Banga JP, et al.: Autoimmune mechanisms in inflammatory eye disease. Trans. Ophthalmol. Soc. UK. 1985; 104: 232–8.
Deschenes J, Char DH, Freeman W, et al.: Uveitis: lymphocyte subpopulation studies. Trans. Ophthalmol. Soc. UK. 1986; 105: 246–51.
Graham E., Spalton DJ, Barnard RO, et al.: Cerebral and retinal vascular changes in systemic lupus erythematosus. Ophthalmology 1985; 92: 444–8.
Dumonde DC, Kasp E, Graham E, et al.: Antiretinal autoimmunity and circulating immune complexes in patients with retinal vasculitis. Lancet. 1982; (ii): 787–92.
Kasp E, Banga JP, Sanders MD, et al.: A novel approach for the purification of human, porceine and bovine S-antigen utilizing hydrophobic absorption chromatography. In Suppl. Invest. Ophthal. Vis. Sci. (ARVO Abstracts) 1985; 26(3): p 97.
Gery I, Mochizuki M, Nussenblatt RB : Retinal specific antigens and Immunopathological Processes they provoke. In Progress in Retinal Research Eds. N. Osborne, J. Chader. Pergamon Press, Oxford. 1986: 75–109.
Forrester JV, Borthwick GM, McMenamin PG : Ultrastructural pathology of S-antigen uveoretinitis. Invest. Ophth. Vis. Sci. 1985; 26: 1281–92.
Wacker WB, Rao NA, Marak GE : Immunopathologic responses of rabbits to retina ‘S’ antigen. I: Phlogistic characteristics associated with antigen source and sensitising dose. Ophthalmic Res. 1981; 13: 302–11.
Gregerson DS, Abrahams IW, Thirkill CE : Serum antibody levels of uveitis patients to bovine retinal antigens. Invest. Ophth. Vis. Sci. 1981; 21: 669–80.
Mochizuki M, Kuwabara T, McAllister C, et al.: Adoptive transfer of experimental autoimmune uveoretinitis in rats: immunopathogenic mechanisms and histological features. Invest. Ophth. Vis. Sci. 1985; 26: 1–9.
Nussenblatt RB, Kuwabara T, DeMonasterio FM, et al.: S-antigen uveitis in primates: a new model for human disease. Arch. Ophthalmol. 1981; 99: 1090–92.
Marak GE, Rao NA : Retinal ‘s’ antigen disease in rats. Ophthalmic Res. 1982; 14: 29–39.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stanford, M., Graham, E., Kasp, E. et al. Retinal vasculitis: Correlation of animal and human disease. Eye 1, 69–77 (1987). https://doi.org/10.1038/eye.1987.11
Issue date:
DOI: https://doi.org/10.1038/eye.1987.11
This article is cited by
-
Molecular size of retinal vascular leakage determined by FITC-dextran angiography in patients with posterior uveitis
Eye (1991)
-
Bilateral visual loss with eosinophilic infiltration in the bone marrow and the retina
International Ophthalmology (1990)
-
Haematological changes in retinal vasculitis
Eye (1988)
