Abstract
This paper reports the microbiological aspects of zosteriform spread of herpes simplex virus (HSV) to the eye in the NIH strain of inbred mouse. Microbiological data support the concept of true zosteriform spread of herpes simplex virus from the inoculation site on the snout to the trigeminal ganglion, and thence to the eye.
Following zosteriform spread of HSV to the eye, there is a frequent bacterial superinfection and this is associated with a typical clinical picture. Treatment of the mice with intensive systemic and topical antibiotics is able to alter the frequency with which this type of keratitis is seen.
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References
Teague O, and Goodpasture EW . Experimental herpes zoster. J Med Res, 44, 185–200.
Blyth WA, Harbour DA, Hill TJ . Pathogenesis of zosteriform spread of herpes simplex virus in the mouse. J Gen Virol, 1984, 65, 1477–86.
Shimeld C, Easty DL, Tullo AB, Blyth WA, Hill TJ . Spread of herpes simplex virus to the eye following cutaneous inoculation in the skin of the snout of the mouse, in Maudgal, P.C. & Missoten, L. (editors), Documenta Ophthalmological Proceedings Series 44 Herpetic Eye Diseases, Dordrecht, Kluwer Academic Publishers/Dr. W. Junk, 1985, pp 39–45.
Claoué CMP, Hill TJ, Blyth WA . Easty DL, Clinical findings after zosteriform spread of herpes simplex virus to the eye of the mouse. Curr. Eye Res., 1987, 6, 281–6.
Hill TJ, Field HJ, Blyth WA . Acute and Recurrent infection with herpes simplex virus in the mouse: A model for studying latency and recurrent disease. J. Gen. Virol., 1975, 28, 341–53.
Shimeld C, Lewkowicz-Moss S, Lipworth KM, Hill TJ, Blyth WA, Easty DL . Antigens of herpes simplex virus in whole corneal epithelial sheets from mice. Arch. Ophthalmol., 1986, 104, 1830–4.
Cowan ST . Cowan and Steel's Manual for the Identification of Medical Bacteria, 2nd edition. Cambridge, Cambridge University Press, 1974.
Claoué CMP . A new look at experimental herpes simplex eye disease. Preliminary results of clinical disease after zosteriform spread to the eye in the NIH mouse. Trans. Ophthalmol. Soc. U.K., 1986, 105, 401–3.
Claoué CMP, Hodges TJ, Hill TJ, Blyth WA, Easty DL . The Histology of the eye after zosteriform spread of herpes simplex virus in the mouse. Br. J. Exp. Path. (in press).
Anderson JR and Field HJ . An Animal model of ocular herpes; keratitis, retinitis and cataract in the mouse. Br. J. Exp. Path., 1984, 65, 283–97.
Russell RG, Nassisse MP, Larsen HS, Rouse BT . Role of t-lymphocytes in the pathogenesis of herpetic stromal keratitis. Invest. Ophthalmol. Vis. Sci., 1984, 25, 938–44.
Williams LE, Nesburn AB, Kaufman HE . Experimental induction of disciform keratitis. Arch. Ophthalmol., 1965, 73, 112–4.
Maudgal PC, de Clercq K, Descamps J, Missoten L . Topical treatment of experimental herpes simplex keratouveitis with 2′-O-glycylacyclovir. Arch. Ophthalmol., 1984, 102, 140–2.
Meyers RL and Pettit TH . The pathogenesis of corneal inflammation due to herpes simplex virus. I. Corneal hypersensitivity in the rabbit. J. Immunol., 1983, 111, 1031–42.
Shimeld C, Dyson H, Lewkowicz-Moss S, Hill TJ, Blyth WA, Easty DL . Spread of HSV1 to the mouse eye after inoculation in the skin requires an intact nerve supply to the inoculation site. Curr. Eye Res., 1987, 6, 9–12.
Simmons A and Nash AA . Zosteriform spread of herpes simplex virus as a model of recrudescence and its use to investigate the role of immune cells in prevention of recurrent disease. J. Virol, 1984, 52, 816–21.
Tullo AB, Easty DL, Hill TJ, Blyth WA . Ocular herpes simplex and the establishment of latent infection. Trans. Ophthalmol. Soc. UK., 1982, 102, 15–8.
Tullo AB, Keen P, Blyth WA, Hill TJ, Easty DL . Corneal sensitivity and substance P in experimental herpes simplex keratitis in mice. Invest. Ophthalmol. vis. Sci, 1983, 24, 596–8.
Hill TJ . Ocular pathogenicity of herpes simplex virus. Curr. Eye Res. 1987, 6, 1–7.
Metcalf JF and Michaelis B . Herpetic keratitis in inbred mice, Invest. Ophthalmol. vis. Sci., 1984, 25, 1222–5.
Tashiro M, Ciborowski P, Klenk H-D, Pulverer G, Rott R . Role of Staphylococcus protease in the development of influenza pneumonia. Nature, 1987, 325, 536–7.
Wilhelmus KR, Falcon MG, Jones Br . Bilateral herpetic keratitis. Br. J. Ophthalmol, 1981, 65, 385–7.
Jones B . The management of ocular herpes. Trans. Ophthalmol. Soc. UK., 1959, 79, 425–37.
Dohlman CH and Zucker BB . Long term treatment with idoxuridine and steroids — a complication of herpetic keratitis. Arch. Ophthalmol., 1965, 74, 172–4.
Wilhelmus KR . Suppurative corneal ulceration following herpetic keratitis. Doc Ophthalmol, 1982, 53, 17–36.
Boisjoly HM, Pavan-Langston D, Kenyon KR, Baker S . Super infection of Herpes Simplex Keratitis. Am. J. Ophthalmol., 1983, 96. 354–61.
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Claoué, C., Hodges, T., Hill, T. et al. Neural spread of herpes simplex virus to the eye of the mouse: Microbiological aspects and effect on the blink reflex. Eye 2, 318–323 (1988). https://doi.org/10.1038/eye.1988.60
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DOI: https://doi.org/10.1038/eye.1988.60
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