Abstract
The role in ocular (limbal) inflammation of the rich vascular and lymphatic supply is discussed in detail. The distribution of lymphocytes, mast cells, Langerhans cells, macrophages and other cellular elements are discussed as well as their individual and collective response to inflammation whether due to infectious or non-infectious disease states. Among the non-infectious causes of limbal cellular inflammation are the four types of hypersensitivity response.
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References
Wolff E : ‘Anatomy of the Eye and Orbit’. Philadelphia: Saunders WB, 1961, pp. 379–381.
Bluestone R : Lacrimal immunoglobulins and complement quantified by counter-immuno-electrophoresis. Br J Ophthalmol 1975, 59: 279–83.
Smolin G and O'Connor GR : Ocular Immunology', Boston, Little, Brown and Co, 1987, p. 76.
Abelson MB and Udell IJ : H2-receptors in the human ocular surface. Arch Ophthalmol 1981, 99: 302–5.
Marom Z and Casale TB : Mast cells and their mediators. Ann Allergy 1983, 50: 367–70.
Goodwin JS and Ceuppers J : Regulation of the immune response by prostaglandins. J Clin Immunol 1983, 3: 295–9.
Gamble CN, Aronson SB, Brescia FB : Experimental uveitis. Arch Ophthalmol 1970, 84: 321–30.
Grabner G, Luger TA, Smolin G, Openheim JJ : Corneal epithelial cell-derived thymocyte activity factor. Invest Ophthalmol Vis Sci 1982, 23: 757–63.
Gillette TE, Chandler JW, Greiner JV : Langerhans of the ocular surface. Ophthalmology 1982, 89: 700–10.
Chandler JW and Gillette TE : Immunologic defense mechanisms of the ocular surface. Ophthalmology 1982, 89: 700–10.
Silberberg-Sinakin E, Baer RL, Thorbecke GJ : Langerhans cells: A review of their nature with emphasis on their immunologie functions. Prog Allergy 1978, 24: 268–94.
Chodirker WB and Thomasi TB Jr: Gamma globulins: Quantitative relationships in human serum and nonvascular fluids. Science 1963, 142: 1080–1.
Jackson EE, Lally ET, Nakamura MC, Montgomery PC : Migration of IgA bearing lymphocytes into salivary glands. Cell Immunol 1981, 63: 203–9.
Bhan AK, Fujikawa L and Foster CS : T-cell subsets and Langerhans cells in normal and diseased conjunctiva. Am J Ophthalmol 1982, 94: 205–12.
Chandler JW and Axelrod AJ : Conjuncitiva-associated lymphoid tissue. In O'Connor GR (ed.), ‘Immunologic Disease of the Mucous Membranes’. New York: Masson, 1980, pp. 63–70.
Bienenstock J, Johnson N, Perey DTE : Bronchial lymphoid tissue 1. Morphologic characteristics. Lab Invest 1973, 28: 686–92.
Hogan MJ : Atopic keratoconjunctivitis. Am J Ophthalmol 1953, 36: 937.
Brown SL : Mooren's ulcer. Br J Ophthalmol 1975, 59: 670.
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Smolin, G. Cellular response to inflammation at the limbus. Eye 3, 167–171 (1989). https://doi.org/10.1038/eye.1989.24
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DOI: https://doi.org/10.1038/eye.1989.24